Quantitative Proteomic Analysis of Hepatic Tissue of T2DM Rhesus Macaque
Joint Authors
Du, Tingfu
Lu, Shuaiyao
Jiang, Qinfang
Li, Yun
Ma, Kaili
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Type 2 diabetes mellitus (T2DM) is a metabolic disorder that severely affects human health, but the pathogenesis of the disease remains unknown.
The high-fat/high-sucrose diets combined with streptozotocin- (STZ-) induced nonhuman primate animal model of diabetes are a valuable research source of T2DM.
Here, we present a study of a STZ rhesus macaque model of T2DM that utilizes quantitative iTRAQ-based proteomic method.
We compared the protein profiles in the liver of STZ-treated macaques as well as age-matched healthy controls.
We identified 171 proteins differentially expressed in the STZ-treated groups, about 70 of which were documented as diabetes-related gene in previous studies.
Pathway analyses indicated that the biological functions of differentially expressed proteins were related to glycolysis/gluconeogenesis, fatty acid metabolism, complements, and coagulation cascades.
Expression change in tryptophan metabolism pathway was also found in this study which may be associations with diabetes.
This study is the first to explore genome-wide protein expression in hepatic tissue of diabetes macaque model using HPLC-Q-TOF/MS technology.
In addition to providing potential T2DM biomarkers, this quantitative proteomic study may also shed insights regarding the molecular pathogenesis of T2DM.
American Psychological Association (APA)
Du, Tingfu& Lu, Shuaiyao& Jiang, Qinfang& Li, Yun& Ma, Kaili. 2017. Quantitative Proteomic Analysis of Hepatic Tissue of T2DM Rhesus Macaque. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1174197
Modern Language Association (MLA)
Du, Tingfu…[et al.]. Quantitative Proteomic Analysis of Hepatic Tissue of T2DM Rhesus Macaque. Journal of Diabetes Research No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1174197
American Medical Association (AMA)
Du, Tingfu& Lu, Shuaiyao& Jiang, Qinfang& Li, Yun& Ma, Kaili. Quantitative Proteomic Analysis of Hepatic Tissue of T2DM Rhesus Macaque. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1174197
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174197