Interorgan Crosstalk Contributing to β-Cell Dysfunction
Joint Authors
Tanabe, Katsuya
Amo-Shiinoki, Kikuko
Hatanaka, Masayuki
Tanizawa, Yukio
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Type 2 diabetes mellitus (T2DM) results from pancreatic β-cell failure in the setting of insulin resistance.
In the early stages of this disease, pancreatic β-cells meet increased insulin demand by both enhancing insulin-secretory capacity and increasing β-cell mass.
As the disease progresses, β-cells fail to maintain these compensatory responses.
This involves both extrinsic signals and mediators intrinsic to β-cells, which adversely affect β-cells by impairing insulin secretion, decreasing proliferative capacities, and ultimately causing apoptosis.
In recent years, it has increasingly been recognized that changes in circulating levels of various factors from other organs play roles in β-cell dysfunction and cellular loss.
In this review, we discuss current knowledge of interorgan communications underlying β-cell failure during the progression of T2DM.
American Psychological Association (APA)
Tanabe, Katsuya& Amo-Shiinoki, Kikuko& Hatanaka, Masayuki& Tanizawa, Yukio. 2017. Interorgan Crosstalk Contributing to β-Cell Dysfunction. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1174203
Modern Language Association (MLA)
Tanabe, Katsuya…[et al.]. Interorgan Crosstalk Contributing to β-Cell Dysfunction. Journal of Diabetes Research No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1174203
American Medical Association (AMA)
Tanabe, Katsuya& Amo-Shiinoki, Kikuko& Hatanaka, Masayuki& Tanizawa, Yukio. Interorgan Crosstalk Contributing to β-Cell Dysfunction. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1174203
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174203