High Prevalence of Autoimmune Diabetes and Poor Glycaemic Control among Adults in Madagascar: A Brief Report from a Humanitarian Health Campaign in Ambanja

Abstract EN

Madagascar is a geographically isolated country considered a biodiversity hotspot with unique genomics.

Both the low-income and the geographical isolation represent risk factors for the development of diabetes.

During a humanitarian health campaign conducted in Ambanja, a rural city in the northern part of Madagascar, we identified 42 adult subjects with diabetes and compared their features to 24 randomly enrolled healthy controls.

42.9% (n=18) of diabetic subjects showed HbA1c values ≥ 9.0%.

Unexpectedly, waist circumference and BMI were similar in people with diabetes and controls.

Different from the healthy controls, diabetic subjects showed a low prevalence of obesity (5.7% versus 30%, p=0.02).

Accordingly, we found a high prevalence of autoimmune diabetes as 12% of people with diabetes showed positivity for the autoantibody against glutamic acid decarboxylase.

Diabetic subjects with positive autoantibody had higher HbA1c values (11.3 ± 4.1% versus 8.3 ± 2.6%, p=0.03) compared to diabetic subjects with negative autoantibody.

In conclusion, here we describe the presence of diabetes and its features in a rural area of Northern Madagascar, documenting poor glycaemic control and a high prevalence of autoimmune diabetes.

These data highlight that the diabetes epidemic involves every corner of the world possibly with different patterns and features.