Urinary Microvesicle-Bound Uromodulin: A Potential Molecular Biomarker in Diabetic Kidney Disease
Joint Authors
Sun, Ai-li
Ni, Yi-hong
Lou, Neng-jun
Jia, Hong-ying
Deng, Jing-ti
Jiang, Lu
Zheng, Feng-jie
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study was designed to investigate the changes of urinary microvesicle-bound uromodulin and total urinary uromodulin levels in human urine and the correlations with the severity of diabetic kidney disease (DKD).
31 healthy subjects without diabetes and 100 patients with type 2 diabetes mellitus (T2DM) were included in this study.
The patients with T2DM were divided into three groups based on the urinary albumin/creatinine ratio (UACR): normoalbuminuria group (DM, n=46); microalbuminuria group (DN1, n=32); and macroalbuminuria group (DN2, n=22).
We use a specific monoclonal antibody AD-1 to capture the urinary microvesicles.
Urinary microvesicle-bound uromodulin and total urinary uromodulin levels were determined by enzyme-linked immunosorbent assay (ELISA).
Our results showed that the levels of urinary microvesicle-bound uromodulin in DN1 and DN2 groups were significantly higher than those in control group and DM group (P<0.01).
Multiple stepwise linear regression analysis showed that UACR was independent determinant for urinary microvesicle-bound uromodulin (P<0.05) but not for total urinary uromodulin.
These findings suggest that the levels of urinary microvesicle-bound uromodulin are associated with the severity of DKD.
The uromodulin in urinary microvesicles may be a specific marker of DKD and potentially may be used to predict the onset and/or monitor the progression of DKD.
American Psychological Association (APA)
Lou, Neng-jun& Ni, Yi-hong& Jia, Hong-ying& Deng, Jing-ti& Jiang, Lu& Zheng, Feng-jie…[et al.]. 2017. Urinary Microvesicle-Bound Uromodulin: A Potential Molecular Biomarker in Diabetic Kidney Disease. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1174224
Modern Language Association (MLA)
Lou, Neng-jun…[et al.]. Urinary Microvesicle-Bound Uromodulin: A Potential Molecular Biomarker in Diabetic Kidney Disease. Journal of Diabetes Research No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1174224
American Medical Association (AMA)
Lou, Neng-jun& Ni, Yi-hong& Jia, Hong-ying& Deng, Jing-ti& Jiang, Lu& Zheng, Feng-jie…[et al.]. Urinary Microvesicle-Bound Uromodulin: A Potential Molecular Biomarker in Diabetic Kidney Disease. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1174224
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174224