Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study
Joint Authors
Szaflik, Jerzy
Szaflik, Jacek P.
Piątkiewicz, Paweł
Zaleska-Żmijewska, Anna
Wawrzyniak, Zbigniew M.
Śmigielska, Barbara
Sokołowska-Oracz, Anna
Romaniuk, Dorota
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Patients with prediabetes are at risk for diabetes, cardiovascular events, and microvascular complications.
The rtx1 (Imagine Eyes, France) permits early detection of changes in the retinal photoreceptors and vessels.
Objective.
Cone parameters and retinal microvasculature were analyzed with the rtx1 in 12 prediabetic patients and 22 healthy subjects.
The analysis was based on cone density (DM), interphotoreceptor distance (SM), cone packing regularity, and retinal vessel parameters: wall thickness, lumen diameter (LD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall.
Results.
DM in the prediabetic group was not significantly lower than that in the control group (18,935 ± 1713 cells/mm2 and 19,900 ± 2375 cells/mm2, respectively; p=0.0928).
The LD and WLR means differed significantly between the prediabetic and the control groups (LD 94.3 ± 10.9 versus 101.2 ± 15, p=0.022; WLR 0.29 ± 0.05 versus 0.22 ± 0.03, p<0.05).
A multivariate regression analysis showed that the WLR was significantly correlated with BMI and total cholesterol.
Conclusions.
Abnormalities found in rtx1 examinations indicated early signs of arteriolar dysfunction, prior to impaired glucose tolerance progressing to diabetes.
The rtx1 retinal image analysis offers noninvasive measurement of early changes in the vasculature that routine clinical examination cannot detect.
American Psychological Association (APA)
Zaleska-Żmijewska, Anna& Piątkiewicz, Paweł& Śmigielska, Barbara& Sokołowska-Oracz, Anna& Wawrzyniak, Zbigniew M.& Szaflik, Jacek P.…[et al.]. 2017. Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1174254
Modern Language Association (MLA)
Szaflik, Jacek P.…[et al.]. Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study. Journal of Diabetes Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1174254
American Medical Association (AMA)
Zaleska-Żmijewska, Anna& Piątkiewicz, Paweł& Śmigielska, Barbara& Sokołowska-Oracz, Anna& Wawrzyniak, Zbigniew M.& Szaflik, Jacek P.…[et al.]. Retinal Photoreceptors and Microvascular Changes in Prediabetes Measured with Adaptive Optics (rtx1™): A Case-Control Study. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1174254
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174254