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Microvesicles Correlated with Components of Metabolic Syndrome in Men with Type 2 Diabetes Mellitus and Lowered Testosterone Levels But Were Unaltered by Testosterone Therapy
Joint Authors
Nielsen, M. H.
Handberg, A.
Botha, Jaco
Velling Magnussen, Line
Nielsen, Tine Bo
Højlund, Kurt
Andersen, Marianne Skovsager
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aims.
To investigate how circulating microvesicle phenotypes correlate with insulin sensitivity, body composition, plasma lipids, and hepatic fat accumulation.
We hypothesized that changes elicited by testosterone replacement therapy are reflected in levels of microvesicles.
Methods.
Thirty-nine type 2 diabetic males with lowered testosterone levels were assigned to either testosterone replacement therapy or placebo and evaluated at baseline and after 24 weeks.
Microvesicles were analysed by flow cytometry and defined as lactadherin-binding particles within the 0.1–1.0 μm gate.
Microvesicles of platelet, monocyte, and endothelial cell origin were identified by cell-specific markers and their expression of CD36 was investigated.
Results.
Triglycerides correlated positively with all investigated microvesicle phenotypes in this study (p<0.05), and indicators of hepatic fat accumulation, alanine aminotransferase, and gamma glutamyltransferase correlated with platelet and endothelial microvesicles and CD36-expressing microvesicles from platelets and monocytes (p<0.05).
BMI, waist circumference, and fat percentage correlated with CD36-expressing monocyte microvesicles (p<0.05), while insulin sensitivity did not correlate with any microvesicle phenotypes.
Microvesicle levels were unaffected by testosterone therapy.
Conclusions.
Metabolic syndrome components and hepatic fat accumulation correlated with microvesicle phenotypes, supporting the involvement of especially CD36 on monocytes in metabolic syndrome pathogenesis.
Although testosterone therapy improved body composition measures, microvesicle phenotype levels were unaffected.
This trial was registered at ClinicalTrials.gov (NCT01560546).
American Psychological Association (APA)
Botha, Jaco& Velling Magnussen, Line& Nielsen, M. H.& Nielsen, Tine Bo& Højlund, Kurt& Andersen, Marianne Skovsager…[et al.]. 2017. Microvesicles Correlated with Components of Metabolic Syndrome in Men with Type 2 Diabetes Mellitus and Lowered Testosterone Levels But Were Unaltered by Testosterone Therapy. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1174264
Modern Language Association (MLA)
Botha, Jaco…[et al.]. Microvesicles Correlated with Components of Metabolic Syndrome in Men with Type 2 Diabetes Mellitus and Lowered Testosterone Levels But Were Unaltered by Testosterone Therapy. Journal of Diabetes Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1174264
American Medical Association (AMA)
Botha, Jaco& Velling Magnussen, Line& Nielsen, M. H.& Nielsen, Tine Bo& Højlund, Kurt& Andersen, Marianne Skovsager…[et al.]. Microvesicles Correlated with Components of Metabolic Syndrome in Men with Type 2 Diabetes Mellitus and Lowered Testosterone Levels But Were Unaltered by Testosterone Therapy. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1174264
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174264