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Rs46522 in the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with the Risk of Coronary Artery Disease in Individuals of Chinese Han Population with Type 2 Diabetes
Joint Authors
Zhang, Junqing
Guo, Xiaohui
Ma, Xiaowei
Zhang, Hong
Lu, Difei
Huang, Jia
Gu, Nan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aims.
We investigated the association between ubiquitin-conjugating enzyme E2Z (UBE2Z) gene SNP rs46522 and the risk of CAD in a Chinese Han population with type 2 diabetes and explored a possible interactive effect with environmental risk factors of CAD.
Methods.
665 patients with T2D were enrolled; 390 were CAD patients and 275 were non-CAD patients.
Genotype analysis of rs46522 (T>C) was performed using PCR-RFLP.
Results.
The SNP rs47522 was associated with the risk of CAD supposing recessive inheritance model (TT versus CC+CT, OR′=1.277, 95%CI′ 1.039–1.570, p′=0.020) and codominant model (TT versus CT, OR′=1.673, 95%CI′ 1.088–2.570, p′=0.019) after adjustment for confounders of CAD.
A synergistic effect of rs46522 and BMI was discovered (β=0.012, p for interreaction = 0.028).
In subgroup analysis, minor allele T was significantly associated with CAD in overweight and obesity subgroup (p=0.034), and the association was also proved in recessive model (OR=1.537, 95%CI 1.075–2.196, p=0.018).
Smokers with genotype TT had threefold risk of CAD in comparison to nonsmokers with genotype TC or CC (p<0.001).
Conclusions.
The SNP rs46522 in UBE2Z gene is associated with the risk of CAD in the individuals of Chinese Han descent with type 2 diabetes and is of synergistic effect with BMI.
American Psychological Association (APA)
Lu, Difei& Huang, Jia& Ma, Xiaowei& Gu, Nan& Zhang, Junqing& Zhang, Hong…[et al.]. 2017. Rs46522 in the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with the Risk of Coronary Artery Disease in Individuals of Chinese Han Population with Type 2 Diabetes. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1174298
Modern Language Association (MLA)
Lu, Difei…[et al.]. Rs46522 in the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with the Risk of Coronary Artery Disease in Individuals of Chinese Han Population with Type 2 Diabetes. Journal of Diabetes Research No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1174298
American Medical Association (AMA)
Lu, Difei& Huang, Jia& Ma, Xiaowei& Gu, Nan& Zhang, Junqing& Zhang, Hong…[et al.]. Rs46522 in the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with the Risk of Coronary Artery Disease in Individuals of Chinese Han Population with Type 2 Diabetes. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1174298
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174298