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Poly(lactic-co-glycolic acid) Nanoparticles Loaded with Callistemon citrinus Phenolics Exhibited Anticancer Properties against Three Breast Cancer Cell Lines
Joint Authors
Ahmed, Rashid
Tariq, Muhammad
Fouly, Hanafy
Fakhar-i-Abbas, Hanafy
Hasan, Anwarul
Kushad, Mosbah
Ahmad, Irfan
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-01
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Fruit and vegetable diets rich in phenolic compounds reduce the risk of various cancers and offer multiple other health benefits due to their bioactivity and powerful antioxidant properties.
However, the human health benefits of most phenolic compounds are restricted due to their limited aqueous solubility, low absorption, restricted passive cellular efflux, and poor gastrointestinal stability.
Nanotechnology has been used to deliver various therapeutic drugs to specific targets overcoming many of the limitations of direct treatments.
This study was designed to develop poly(lactic-co-glycolic acid) (PLGA) nanoencapsulated phenolic-rich extracts from Callistemon citrinus and berberine and to evaluate their effectiveness against extremely invasive MDA-MB 231, moderately invasive MCF-10A, and minimally invasive MCF-7 breast cancers.
We have achieved about 80% encapsulation of phenolics from C.
citrinus.
Most encapsulated nanoparticles were polygonal with particles sizes of 200 to 250 nm.
Release of phenolics from encapsulation during storage was biphasic during the first week and then levelled off thereafter.
Nanoencapsulated phenolics from C.
citrinus extract, berberine, and combination of both enhanced their bioactivity against the three breast cancer cell lines by nearly 2-fold.
Growth inhibition of cells was a linear curve relative to phenolic concentration, with a maximum inhibition of nearly 100% at 0.1 mg/ml compared to control.
American Psychological Association (APA)
Ahmed, Rashid& Tariq, Muhammad& Ahmad, Irfan& Fouly, Hanafy& Fakhar-i-Abbas, Hanafy& Hasan, Anwarul…[et al.]. 2019. Poly(lactic-co-glycolic acid) Nanoparticles Loaded with Callistemon citrinus Phenolics Exhibited Anticancer Properties against Three Breast Cancer Cell Lines. Journal of Food Quality،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1174319
Modern Language Association (MLA)
Ahmed, Rashid…[et al.]. Poly(lactic-co-glycolic acid) Nanoparticles Loaded with Callistemon citrinus Phenolics Exhibited Anticancer Properties against Three Breast Cancer Cell Lines. Journal of Food Quality No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1174319
American Medical Association (AMA)
Ahmed, Rashid& Tariq, Muhammad& Ahmad, Irfan& Fouly, Hanafy& Fakhar-i-Abbas, Hanafy& Hasan, Anwarul…[et al.]. Poly(lactic-co-glycolic acid) Nanoparticles Loaded with Callistemon citrinus Phenolics Exhibited Anticancer Properties against Three Breast Cancer Cell Lines. Journal of Food Quality. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1174319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174319