Neutrophils Infiltrate the Spinal Cord Parenchyma of Rats with Experimental Diabetic Neuropathy
Joint Authors
Newton, Victoria L.
Guck, Jonathan D.
Cotter, Mary A.
Gardiner, Natalie J.
Cameron, Norman
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Spinal glial cell activation and cytokine secretion have been implicated in the etiology of neuropathic pain in a number of experimental models, including diabetic neuropathy.
In this study, streptozotocin- (STZ-) induced diabetic rats were either untreated or treated with gabapentin (50 mg/kg/day by gavage for 2 weeks, from 6 weeks after STZ).
At 8 weeks after STZ, hypersensitivity was confirmed in the untreated diabetic rats as a reduced response threshold to touch, whilst mechanical thresholds in gabapentin-treated diabetic rats were no different from controls.
Diabetes-associated thermal hypersensitivity was also ameliorated by gabapentin.
We performed a cytokine profiling array in lumbar spinal cord samples from control and diabetic rats.
This revealed an increase in L-selectin, an adhesion molecule important for neutrophil transmigration, in the spinal cord of diabetic rats but not diabetic rats treated with gabapentin.
Furthermore, we found an increase in the number of neutrophils present in the parenchyma of the spinal cord, which was again ameliorated in gabapentin-treated diabetic rats.
Therefore, we suggest that dysregulated spinal L-selectin and neutrophil infiltration into the spinal cord could contribute to the pathogenesis of painful diabetic neuropathy.
American Psychological Association (APA)
Newton, Victoria L.& Guck, Jonathan D.& Cotter, Mary A.& Cameron, Norman& Gardiner, Natalie J.. 2017. Neutrophils Infiltrate the Spinal Cord Parenchyma of Rats with Experimental Diabetic Neuropathy. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1174329
Modern Language Association (MLA)
Newton, Victoria L.…[et al.]. Neutrophils Infiltrate the Spinal Cord Parenchyma of Rats with Experimental Diabetic Neuropathy. Journal of Diabetes Research No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1174329
American Medical Association (AMA)
Newton, Victoria L.& Guck, Jonathan D.& Cotter, Mary A.& Cameron, Norman& Gardiner, Natalie J.. Neutrophils Infiltrate the Spinal Cord Parenchyma of Rats with Experimental Diabetic Neuropathy. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1174329
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174329