PNPLA3 rs1010023 Predisposes Chronic Hepatitis B to Hepatic Steatosis but Improves Insulin Resistance and Glucose Metabolism
Joint Authors
Pan, Qin
Fan, Jian-Gao
Wang, Yu-Qin
Chen, Mei-Mei
Zhang, Rui-Nan
Zheng, Rui-Dan
Mi, Yu-Qiang
Liu, Wen-Bin
Shen, Feng
Su, Qing
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
PNPLA3 polymorphisms serve as the genetic basis of hepatic steatosis in normal population and lead to dysregulated glucose metabolism.
Whether it underlies the hepatic steatosis and glucose homeostasis in chronic hepatitis B patients remains uncertain.
Here, we investigated the PNPLA3 polymorphisms in biopsy-proven chronic hepatitis B patients with (CHB+HS group, n=52) or without hepatic steatosis (CHB group, n=47) and non-CHB subjects with (HS group, n=37) or without hepatic steatosis (normal group, n=45).
When compared to the TT genotype, C-allele at PNPLA3 rs1010023 (CC and TC genotypes) conferred higher risk to hepatic steatosis in chronic hepatitis B patients (odds ratio (OR) = 1.768, 95% confidence interval (CI): 1.027–3.105; P=0.045) independent of age, gender, and body mass index.
In contrast to their role in hepatic steatosis, CC and TC genotypes of PNPLA3 rs1010023 were correlated to significant improvement of homeostasis model assessment index (HOMA-IR) as compared to TT genotype in the CHB+HS group.
Downregulated fasting blood glucose also characterized the CHB+HS patients with C-allele at PNPLA3 rs1010023 (CC/TC versus TT: 4.81 ± 0.92 mmol/L versus 5.86 ± 2.11 mmol/L, P=0.02).
These findings suggest that PNPLA3 rs1010023 may predispose chronic hepatitis B patients to hepatic steatosis but protects them from glucose dysregulation by attenuating insulin resistance.
American Psychological Association (APA)
Pan, Qin& Chen, Mei-Mei& Zhang, Rui-Nan& Wang, Yu-Qin& Zheng, Rui-Dan& Mi, Yu-Qiang…[et al.]. 2017. PNPLA3 rs1010023 Predisposes Chronic Hepatitis B to Hepatic Steatosis but Improves Insulin Resistance and Glucose Metabolism. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1174352
Modern Language Association (MLA)
Pan, Qin…[et al.]. PNPLA3 rs1010023 Predisposes Chronic Hepatitis B to Hepatic Steatosis but Improves Insulin Resistance and Glucose Metabolism. Journal of Diabetes Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1174352
American Medical Association (AMA)
Pan, Qin& Chen, Mei-Mei& Zhang, Rui-Nan& Wang, Yu-Qin& Zheng, Rui-Dan& Mi, Yu-Qiang…[et al.]. PNPLA3 rs1010023 Predisposes Chronic Hepatitis B to Hepatic Steatosis but Improves Insulin Resistance and Glucose Metabolism. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1174352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174352