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Correlates of Calcaneal Quantitative Ultrasound Parameters in Patients with Diabetes: The Study on the Assessment of Determinants of Muscle and Bone Strength Abnormalities in Diabetes
Joint Authors
Nicolucci, Antonio
Menini, Stefano
Iacobini, Carla
Pugliese, Giuseppe
Conti, Francesco
Balducci, Stefano
Pugliese, Luca
D’Errico, Valeria
Vitale, Martina
Alessi, Elena
Bollanti, Lucilla
Salerno, Gerardo
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
Quantitative ultrasound (QUS) provides an estimate of bone mineral density (BMD) and also evaluates bone quality, which has been related to increased fracture risk in people with diabetes.
This study aimed at assessing the correlates of calcaneal QUS parameters in diabetic subjects encompassing various degrees of micro and macrovascular complications and a wide-range of peripheral nerve function.
Methods.
Four hundred consecutive diabetic patients were examined by QUS to obtain values of broadband ultrasound attenuation (BUA), the speed of sound (SOS), quantitative ultrasound index (QUI), and BMD.
Results.
Among surrogate measures of complications, sensory and motor nerve amplitude and heart rate response to cough test and standing correlated with QUS parameters at univariate analysis, together with age, body mass index (BMI), waist circumference, lipid profile, and renal function.
Multivariate analysis revealed that BUA, SOS, QUI, and BMD were independently associated with age, male gender, hemoglobin A1c, BMI (or fat, but not fat-free mass), and somatic and autonomic nerve function parameters.
Conclusions.
These data indicate that peripheral nerve dysfunction is associated with worse QUS parameters, possibly contributing to increased fracture risk in diabetes.
The positive relation of QUS measures with adiposity needs further investigation.
This trial is registered with ClinicalTrials.gov (NCT01600924).
American Psychological Association (APA)
Conti, Francesco& Balducci, Stefano& Pugliese, Luca& D’Errico, Valeria& Vitale, Martina& Alessi, Elena…[et al.]. 2017. Correlates of Calcaneal Quantitative Ultrasound Parameters in Patients with Diabetes: The Study on the Assessment of Determinants of Muscle and Bone Strength Abnormalities in Diabetes. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1174357
Modern Language Association (MLA)
Conti, Francesco…[et al.]. Correlates of Calcaneal Quantitative Ultrasound Parameters in Patients with Diabetes: The Study on the Assessment of Determinants of Muscle and Bone Strength Abnormalities in Diabetes. Journal of Diabetes Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1174357
American Medical Association (AMA)
Conti, Francesco& Balducci, Stefano& Pugliese, Luca& D’Errico, Valeria& Vitale, Martina& Alessi, Elena…[et al.]. Correlates of Calcaneal Quantitative Ultrasound Parameters in Patients with Diabetes: The Study on the Assessment of Determinants of Muscle and Bone Strength Abnormalities in Diabetes. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1174357
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174357