![](/images/graphics-bg.png)
The Nrf2Keap1ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus
Joint Authors
Rifkin, William J.
Ceradini, Daniel J.
David, Joshua A.
Rabbani, Piul S.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-20
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Despite improvements in awareness and treatment of type II diabetes mellitus (TIIDM), this disease remains a major source of morbidity and mortality worldwide, and prevalence continues to rise.
Oxidative damage caused by free radicals has long been known to contribute to the pathogenesis and progression of TIIDM and its complications.
Only recently, however, has the role of the Nrf2/Keap1/ARE master antioxidant pathway in diabetic dysfunction begun to be elucidated.
There is accumulating evidence that this pathway is implicated in diabetic damage to the pancreas, heart, and skin, among other cell types and tissues.
Animal studies and clinical trials have shown promising results suggesting that activation of this pathway can delay or reverse some of these impairments in TIIDM.
In this review, we outline the role of oxidative damage and the Nrf2/Keap1/ARE pathway in TIIDM, focusing on current and future efforts to utilize this relationship as a therapeutic target for prevention, prognosis, and treatment of TIID.
American Psychological Association (APA)
David, Joshua A.& Rifkin, William J.& Rabbani, Piul S.& Ceradini, Daniel J.. 2017. The Nrf2Keap1ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1174367
Modern Language Association (MLA)
David, Joshua A.…[et al.]. The Nrf2Keap1ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus. Journal of Diabetes Research No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1174367
American Medical Association (AMA)
David, Joshua A.& Rifkin, William J.& Rabbani, Piul S.& Ceradini, Daniel J.. The Nrf2Keap1ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1174367
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174367