Metformin Improves Overall Survival of Colorectal Cancer Patients with Diabetes: A Meta-Analysis
Joint Authors
Meng, Fanqiang
Song, Li
Wang, Wenyue
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Diabetic population has a higher risk of colorectal cancer (CRC) incidence and mortality than nondiabetics.
The role of metformin in CRC prognosis is still controversial.
The meta-analysis aims to investigate whether metformin improves the survival of diabetic CRC patients.
Methods.
PubMed, EMBASE, and Cochrane Library were searched till July 1, 2016.
Cohort studies were included.
All articles were evaluated by Newcastle-Ottawa Scale.
Hazard Ratios (HRs) with 95% confidence intervals (CIs) for each study were calculated and pooled HRs with corresponding 95% CIs were generated using the random-effects model.
Heterogeneity and publication bias were assessed.
Results.
We included seven cohort studies with a medium heterogeneity (I2 = 56.1% and p=0.033) in our meta-analysis.
An improved overall survival (OS) for metformin users over nonusers among colorectal cancers with diabetes was noted (HR 0.75; 95% CI 0.65 to 0.87).
However, metformin reveals no benefits for cancer-specific survival (HR 0.79, 95%, CI 0.58 to 1.08).
Conclusions.
Metformin prolongs the OS of diabetic CRC patients, but it does not affect the CRC-specific survival.
Metformin may be a good choice in treating CRC patients with diabetes mellitus in clinical settings.
American Psychological Association (APA)
Meng, Fanqiang& Song, Li& Wang, Wenyue. 2017. Metformin Improves Overall Survival of Colorectal Cancer Patients with Diabetes: A Meta-Analysis. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1174389
Modern Language Association (MLA)
Meng, Fanqiang…[et al.]. Metformin Improves Overall Survival of Colorectal Cancer Patients with Diabetes: A Meta-Analysis. Journal of Diabetes Research No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1174389
American Medical Association (AMA)
Meng, Fanqiang& Song, Li& Wang, Wenyue. Metformin Improves Overall Survival of Colorectal Cancer Patients with Diabetes: A Meta-Analysis. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1174389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174389