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Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes
Joint Authors
Mega, Cristina
Teixeira de Lemos, Edite
Fernandes, Rosa
Reis, Flávio
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Diabetic nephropathy (DN) is now the single commonest cause of end-stage renal disease (ESRD) worldwide and one of the main causes of death in diabetic patients.
It is also acknowledged as an independent risk factor for cardiovascular disease (CVD).
Since sitagliptin was approved, many studies have been carried out revealing its ability to not only improve metabolic control but also ameliorate dysfunction in various diabetes-targeted organs, especially the kidney, due to putative underlying cytoprotective properties, namely, its antiapoptotic, antioxidant, anti-inflammatory, and antifibrotic properties.
Despite overall recommendations, many patients spend a long time well outside the recommended glycaemic range and, therefore, have an increased risk for developing micro- and macrovascular complications.
Currently, it is becoming clearer that type 2 diabetes mellitus (T2DM) management must envision not only the improvement in glycaemic control but also, and particularly, the prevention of pancreatic deterioration and the evolution of complications, such as DN.
This review aims to provide an overview of the current knowledge in the field of renoprotective actions of sitagliptin, namely, improvement in diabetic dysmetabolism, hemodynamic factors, renal function, diabetic kidney lesions, and cytoprotective properties.
American Psychological Association (APA)
Mega, Cristina& Teixeira de Lemos, Edite& Fernandes, Rosa& Reis, Flávio. 2017. Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1174405
Modern Language Association (MLA)
Mega, Cristina…[et al.]. Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes. Journal of Diabetes Research No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1174405
American Medical Association (AMA)
Mega, Cristina& Teixeira de Lemos, Edite& Fernandes, Rosa& Reis, Flávio. Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1174405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174405