Risk of Type 2 Diabetes Mellitus following Gestational Diabetes Pregnancy in Women with Polycystic Ovary Syndrome
Joint Authors
Lo, Joan C.
Yang, Jingrong
Gunderson, Erica P.
Hararah, Mohammad K.
Gonzalez, Joel R.
Ferrara, Assiamira
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
This study examines gestational diabetes mellitus (GDM) in women with polycystic ovary syndrome (PCOS) and the risk of type 2 diabetes mellitus (DM) following GDM pregnancy.
Methods.
A cohort of 988 pregnant women with PCOS who delivered during 2002–2005 was examined to determine the prevalence and predictors of GDM, with follow-up through 2010 among those with GDM to estimate the risk of DM.
Results.
Of the 988 pregnant women with PCOS, 192 (19%) developed GDM.
Multivariable predictors of GDM included older age, Asian race, prepregnancy obesity, family history of DM, preconception metformin use, and multiple gestation.
Among women with PCOS and GDM pregnancy, the incidence of DM was 2.8 (95% confidence interval (CI) 1.9–4.2) per 100 person-years and substantially higher for those who received pharmacologic treatment for GDM (6.6 versus 1.5 per 100 person-years, p<0.01).
The multivariable adjusted risk of DM was fourfold higher in women who received pharmacologic treatment for GDM (adjusted hazard ratio 4.1, 95% CI 1.8–9.6).
The five-year incidence of DM was 13.1% overall and also higher in the pharmacologic treatment subgroup (27.0% versus 7.1%, p<0.01).
Conclusions.
The strongest predictors of GDM among women with PCOS included Asian race and prepregnancy obesity.
Pharmacologic treatment of GDM is associated with fourfold higher risk of subsequent DM.
American Psychological Association (APA)
Lo, Joan C.& Yang, Jingrong& Gunderson, Erica P.& Hararah, Mohammad K.& Gonzalez, Joel R.& Ferrara, Assiamira. 2017. Risk of Type 2 Diabetes Mellitus following Gestational Diabetes Pregnancy in Women with Polycystic Ovary Syndrome. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1174423
Modern Language Association (MLA)
Lo, Joan C.…[et al.]. Risk of Type 2 Diabetes Mellitus following Gestational Diabetes Pregnancy in Women with Polycystic Ovary Syndrome. Journal of Diabetes Research No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1174423
American Medical Association (AMA)
Lo, Joan C.& Yang, Jingrong& Gunderson, Erica P.& Hararah, Mohammad K.& Gonzalez, Joel R.& Ferrara, Assiamira. Risk of Type 2 Diabetes Mellitus following Gestational Diabetes Pregnancy in Women with Polycystic Ovary Syndrome. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1174423
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174423