Not Only Glycaemic But Also Other Metabolic Factors Affect T Regulatory Cell Counts and Proinflammatory Cytokine Levels in Women with Type 1 Diabetes
Joint Authors
Filipp, Dominik
Sklenarova-Labikova, Jana
Kratzerova, Tereza
Stechova, Katerina
Pithova, Pavlina
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Type 1 diabetic (T1D) patients suffer from insulinopenia and hyperglycaemia.
Studies have shown that if a patient’s hyperglycaemic environment is not compensated, it leads to complex immune dysfunctions.
Similarly, T1D mothers with poor glycaemic control exert a negative impact on the immune responses of their newborns.
However, questions concerning the impact of other metabolic disturbances on the immune system of T1D mothers (and their newborns) have been raised.
To address these questions, we examined 28 T1D women in reproductive age for the relationship between various metabolic, clinical, and immune parameters.
Our study revealed several unexpected correlations which are indicative of a much more complex relationship between glucose and lipid factors (namely, glycosylated haemoglobin Hb1Ac, the presence of one but not multiple chronic diabetic complications, and atherogenic indexes) and proinflammatory cytokines (IL-1alpha and TNF-alpha).
Regulatory T cell counts correlated with HbA1c, diabetic neuropathy, lipid spectra parameters, and IL-6 levels.
Total T-helper cell count was interconnected with BMI and glycaemia variability correlated with lipid spectra parameters, insulin dose, and vitamin D levels.
These and other correlations revealed in this study provide broader insight into the association of various metabolic abnormalities with immune parameters that may impact T1D mothers or their developing child.
American Psychological Association (APA)
Stechova, Katerina& Sklenarova-Labikova, Jana& Kratzerova, Tereza& Pithova, Pavlina& Filipp, Dominik. 2017. Not Only Glycaemic But Also Other Metabolic Factors Affect T Regulatory Cell Counts and Proinflammatory Cytokine Levels in Women with Type 1 Diabetes. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1174443
Modern Language Association (MLA)
Stechova, Katerina…[et al.]. Not Only Glycaemic But Also Other Metabolic Factors Affect T Regulatory Cell Counts and Proinflammatory Cytokine Levels in Women with Type 1 Diabetes. Journal of Diabetes Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1174443
American Medical Association (AMA)
Stechova, Katerina& Sklenarova-Labikova, Jana& Kratzerova, Tereza& Pithova, Pavlina& Filipp, Dominik. Not Only Glycaemic But Also Other Metabolic Factors Affect T Regulatory Cell Counts and Proinflammatory Cytokine Levels in Women with Type 1 Diabetes. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1174443
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174443