Synergistic Effect of the MTHFR C677T and EPHX2 G860A Polymorphism on the Increased Risk of Ischemic Stroke in Chinese Type 2 Diabetic Patients
Joint Authors
Zhang, Haojun
Zhao, Tingting
Li, Ping
Yan, Meihua
Ma, Liang
Zhao, Hailing
Liu, Qian
Jiang, Yongwei
Cao, Yongtong
Kong, Xiaomu
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study was to investigate the relationship between the combined effect of MTHFR C677T (rs1801133) and EPHX2 G860A (rs751141) polymorphism and ischemic stroke in Chinese T2DM patients.
This case-control study included a total of 626 Chinese T2DM patients (236 T2DM patients with ischemic stroke and 390 T2DM patients without ischemic stroke).
The rs1801133 and rs751141 were genotyped using real-time polymerase chain reaction.
Statistical analysis was performed with SPSS 17.0.
Results showed that the combined effect of MTHFR TT and EPHX2 GG or GA + AA genotype has a higher risk of ischemic stroke compared with the control group (combined effect of MTHFR CC and EPHX2 GA + AA genotypes; OR = 3.46 and OR = 3.42, resp.; P=.001 and P=.002, resp.).
The A allele showed marked association with a lower risk of ischemic stroke in patients with the lowest Hcy levels under additive, recessive, and dominant genetic models (OR = 0.45, OR = 0.11, and OR = 0.44, resp.; P=.002, P=.035, and P=.008, resp.), which was not observed in medium or high Hcy level groups.
In conclusion, the T allele of rs1801133 and the G allele of rs751141 may be risk factors of ischemic stroke in the Chinese T2DM population.
American Psychological Association (APA)
Ma, Liang& Jiang, Yongwei& Kong, Xiaomu& Yan, Meihua& Zhao, Tingting& Zhao, Hailing…[et al.]. 2017. Synergistic Effect of the MTHFR C677T and EPHX2 G860A Polymorphism on the Increased Risk of Ischemic Stroke in Chinese Type 2 Diabetic Patients. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1174552
Modern Language Association (MLA)
Ma, Liang…[et al.]. Synergistic Effect of the MTHFR C677T and EPHX2 G860A Polymorphism on the Increased Risk of Ischemic Stroke in Chinese Type 2 Diabetic Patients. Journal of Diabetes Research No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1174552
American Medical Association (AMA)
Ma, Liang& Jiang, Yongwei& Kong, Xiaomu& Yan, Meihua& Zhao, Tingting& Zhao, Hailing…[et al.]. Synergistic Effect of the MTHFR C677T and EPHX2 G860A Polymorphism on the Increased Risk of Ischemic Stroke in Chinese Type 2 Diabetic Patients. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1174552
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174552