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Association between STK11 Gene Polymorphisms and Coronary Artery Disease in Type 2 Diabetes in Han Population in China
Joint Authors
Zhang, Jianwei
Guo, Xiaohui
Ma, Xiaowei
Deng, Ruifen
Bai, Ge
Lu, Difei
Gu, Nan
Huang, Linjuan
Ding, Shan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Recent studies indicated that the Serine threonine kinase 11 (STK11), which is a key regulator of the AMP-activated protein kinase (AMPK), plays a crucial role in cardiovascular system.
This study aimed to investigate whether genetic variations in the STK11 gene affect the risk of coronary artery disease (CAD) in Chinese type 2 diabetics.
Methods.
5 haplotype-tagging single nucleotide polymorphisms (SNPs) were selected, and 288 CAD-positive cases and 159 CAD-negative controls with type 2 diabetes were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.
Results.
The carriers of minor allele A at rs12977689 had a higher risk of CAD compared to the homozygotes of CC (OR = 1.572, 95% CI = 1.039–2.376, p=0.035), and the difference was still significant after adjustment for the other known CAD risk factors (OR′ = 1.184, 95% CI′ = 1.036–1.353, p′=0.013).
Conclusion.
Genetic variability at STK11 locus is associated with CAD risk in type 2 diabetes in the Chinese population.
American Psychological Association (APA)
Ma, Xiaowei& Bai, Ge& Lu, Difei& Huang, Linjuan& Zhang, Jianwei& Deng, Ruifen…[et al.]. 2017. Association between STK11 Gene Polymorphisms and Coronary Artery Disease in Type 2 Diabetes in Han Population in China. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1174561
Modern Language Association (MLA)
Ma, Xiaowei…[et al.]. Association between STK11 Gene Polymorphisms and Coronary Artery Disease in Type 2 Diabetes in Han Population in China. Journal of Diabetes Research No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1174561
American Medical Association (AMA)
Ma, Xiaowei& Bai, Ge& Lu, Difei& Huang, Linjuan& Zhang, Jianwei& Deng, Ruifen…[et al.]. Association between STK11 Gene Polymorphisms and Coronary Artery Disease in Type 2 Diabetes in Han Population in China. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1174561
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174561