Gut Microbiome and Inflammation: A Study of Diabetic Inflammasome-Knockout Mice
Joint Authors
Devaraj, Sridevi
Pahwa, Roma
Balderas, Miriam
Jialal, Ishwarlal
Chen, Xinpu
Luna, Ruth Ann
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aims.
Diabetes is a proinflammatory state, evidenced by increased pattern recognition receptors and the inflammasome (NOD-like receptor family pyrin domain (NLRP)) complex.
Recent reports have elucidated the role of the gut microbiome in diabetes, but there is limited data on the gut microbiome in NLRP-KO mice and its effect on diabetes-induced inflammation.
Methods.
Gut microbiome composition and biomarkers of inflammation (IL-18, serum amyloid A) were assessed in streptozotocin- (STZ-) induced diabetic mice on a NLRP3-knockout (KO) background versus wild-type diabetic mice.
Results.
SAA and IL-18 levels were significantly elevated in diabetic mice (STZ) compared to control (WT) mice, and there was a significant attenuation of inflammation in diabetic NLRP3-KO mice (NLRP3-KO STZ) compared to control mice (p<0.005).
Principal coordinate analysis clearly separated controls, STZ, and NLRP3-KO STZ mice.
Among the different phyla, there was a significant increase in the Firmicutes : Bacteroidetes ratio in the diabetic group compared to controls.
When compared to the WT STZ group, the NLRP3-KO STZ group showed a significant decrease in the Firmicutes : Bacteroidetes ratio.
Together, these findings indicate that interaction of the intestinal microbes with the innate immune system is a crucial factor that could modify diabetes and complications.
American Psychological Association (APA)
Pahwa, Roma& Balderas, Miriam& Jialal, Ishwarlal& Chen, Xinpu& Luna, Ruth Ann& Devaraj, Sridevi. 2017. Gut Microbiome and Inflammation: A Study of Diabetic Inflammasome-Knockout Mice. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1174614
Modern Language Association (MLA)
Pahwa, Roma…[et al.]. Gut Microbiome and Inflammation: A Study of Diabetic Inflammasome-Knockout Mice. Journal of Diabetes Research No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1174614
American Medical Association (AMA)
Pahwa, Roma& Balderas, Miriam& Jialal, Ishwarlal& Chen, Xinpu& Luna, Ruth Ann& Devaraj, Sridevi. Gut Microbiome and Inflammation: A Study of Diabetic Inflammasome-Knockout Mice. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1174614
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174614