The Association between Monocyte Surface CD163 and Insulin Resistance in Patients with Type 2 Diabetes
Joint Authors
Mori, Katsuhito
Morioka, Tomoaki
Yamazaki, Yuko
Kawarabayashi, Reina
Motoyama, Koka
Fukumoto, Shinya
Shioi, Atsushi
Shoji, Tetsuo
Emoto, Masanori
Imanishi, Yasuo
Inaba, Masaaki
Nakamura, Miyuki
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
To investigate the association between monocyte CD163 and insulin resistance in patients with type 2 diabetes.
Methods.
One hundred sixty-six patients with type 2 diabetes without inflammatory or chronic kidney disease were recruited.
The monocyte CD163 levels were measured by flow cytometry and soluble CD163 (sCD163) by ELISA.
Insulin resistance was evaluated by the index of the homeostasis model assessment (HOMA-R).
Results.
The median sCD163 and monocyte CD163 expression levels were 582.9 (472.4–720.0) ng/ml and 6061 (4486–7876) mean fluorescent intensity (MFI), respectively.
In a simple regression analysis, monocyte CD163 was inversely correlated with log [HOMA-R] (r=–0.257, p=0.010), and sCD163 was positively correlated with log [HOMA-R] (r=0.198, p=0.042).
In multiple regression analyses, monocyte CD163 was an independent contributor to log [HOMA-R] (β=–0.220, p=0.020) even after adjustment of various clinical factors for HOMA-R (R2=0.281, p=0.001), whereas sCD163 was not.
Conclusions.
Monocyte surface CD163 expression levels were more significantly associated with insulin resistance than sCD163 in patients with type 2 diabetes, suggesting a novel pathophysiological role of CD163.
American Psychological Association (APA)
Kawarabayashi, Reina& Motoyama, Koka& Nakamura, Miyuki& Yamazaki, Yuko& Morioka, Tomoaki& Mori, Katsuhito…[et al.]. 2017. The Association between Monocyte Surface CD163 and Insulin Resistance in Patients with Type 2 Diabetes. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1174621
Modern Language Association (MLA)
Kawarabayashi, Reina…[et al.]. The Association between Monocyte Surface CD163 and Insulin Resistance in Patients with Type 2 Diabetes. Journal of Diabetes Research No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1174621
American Medical Association (AMA)
Kawarabayashi, Reina& Motoyama, Koka& Nakamura, Miyuki& Yamazaki, Yuko& Morioka, Tomoaki& Mori, Katsuhito…[et al.]. The Association between Monocyte Surface CD163 and Insulin Resistance in Patients with Type 2 Diabetes. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1174621
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174621