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Effects of Renal Denervation on Insulin Sensitivity and Inflammatory Markers in Nondiabetic Patients with Treatment-Resistant Hypertension
Joint Authors
Bjerre, Mette
Kampmann, Ulla
Mathiassen, Ole N.
Christensen, Kent L.
Buus, Niels H.
Vase, Henrik
Møller, Niels
Kaltoft, Anne
Poulsen, Per L.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Increased sympathetic activity is important in the pathogenesis of hypertension and insulin resistance.
Afferent signaling from the kidneys elevates the central sympathetic drive.
We investigated the effect of catheter-based renal sympathetic denervation (RDN) on glucose metabolism, inflammatory markers, and blood pressure in nondiabetic patients with treatment-resistant hypertension.
Eight subjects were included in an open-labelled study.
Each patient was studied before and 6 months after RDN.
Endogenous glucose production was assessed by a 3-3H glucose tracer, insulin sensitivity was examined by hyperinsulinemic euglycemic clamp, hormones and inflammatory markers were analyzed, and blood pressure was measured by office blood pressure readings and 24-hour ambulatory blood pressure monitoring.
Insulin sensitivity (M-value) increased nonsignificantly from 2.68 ± 0.28 to 3.07 ± 0.41 (p=0.12).
A significant inverse correlation between the increase in M-value and BMI 6 months after RDN (p=0.03) was found, suggesting beneficial effects on leaner subjects.
Blood pressure decreased significantly, but there were no changes in hormones, inflammatory markers, or endogenous glucose production.
Our results indicate that RDN may improve insulin sensitivity in some patients with treatment-resistant hypertension, albeit confirmation of these indications of beneficial effects on leaner subjects awaits the outcome of larger randomized controlled studies.
American Psychological Association (APA)
Kampmann, Ulla& Mathiassen, Ole N.& Christensen, Kent L.& Buus, Niels H.& Bjerre, Mette& Vase, Henrik…[et al.]. 2017. Effects of Renal Denervation on Insulin Sensitivity and Inflammatory Markers in Nondiabetic Patients with Treatment-Resistant Hypertension. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1174634
Modern Language Association (MLA)
Kampmann, Ulla…[et al.]. Effects of Renal Denervation on Insulin Sensitivity and Inflammatory Markers in Nondiabetic Patients with Treatment-Resistant Hypertension. Journal of Diabetes Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1174634
American Medical Association (AMA)
Kampmann, Ulla& Mathiassen, Ole N.& Christensen, Kent L.& Buus, Niels H.& Bjerre, Mette& Vase, Henrik…[et al.]. Effects of Renal Denervation on Insulin Sensitivity and Inflammatory Markers in Nondiabetic Patients with Treatment-Resistant Hypertension. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1174634
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174634