Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study
Joint Authors
Kwon, Min Jeong
Park, Jeong Hyun
Lee, Soon Hee
Kim, Bo Hyun
Kim, Jong Ho
Kim, Sang Soo
Kim, In Joo
Park, Ja Young
Lee, Chang Won
Suk, Ji Hye
Shin, Sun Hae
Son, Sung Pyo
Kim, Min Chul
Ahn, Jun Hyeob
Lee, Kwang Jae
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
The aim of this study was to evaluate the association between arterial stiffness and albuminuria and glomerular filtration rate (GFR) in patients with type 2 diabetes mellitus.
Methods.
This multicenter cohort study analyzed 2613 patients with type 2 diabetes.
Brachial-ankle pulse wave velocity (baPWV) was used as a noninvasive marker of arterial stiffness.
Additionally, the patients were categorized into four groups according to their albumin-to-creatinine ratio (ACR, normoalbuminuria versus albuminuria) and estimated GFR (eGFR, <60 mL/min/1.73 m2 versus ≥60 mL/min/1.73 m2).
Results.
A univariate analysis revealed that maximal baPWV was significantly associated with both the ACR (r=0.297, P<0.001) and eGFR (r=−0.220, P<0.001).
A multivariate analysis adjusted for significant clinical variables and eGFR showed that baPWV remained significantly correlated with the ACR (r=0.150, P<0.001).
Also, baPWV was correlated positively with the ACR in patients with an eGFR ≥ 60 mL/min/1.73 m2 (r=0.146, P<0.001).
However, baPWV was not correlated with eGFR after adjustment for significant clinical variables.
Conclusions.
The present findings indicate that arterial stiffness is more associated with albuminuria than a decrease in GFR in patients with type 2 diabetes mellitus.
American Psychological Association (APA)
Kim, Jong Ho& Kim, Sang Soo& Kim, In Joo& Kim, Bo Hyun& Park, Ja Young& Lee, Chang Won…[et al.]. 2017. Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1174654
Modern Language Association (MLA)
Kim, Jong Ho…[et al.]. Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study. Journal of Diabetes Research No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1174654
American Medical Association (AMA)
Kim, Jong Ho& Kim, Sang Soo& Kim, In Joo& Kim, Bo Hyun& Park, Ja Young& Lee, Chang Won…[et al.]. Arterial Stiffness Is More Associated with Albuminuria than Decreased Glomerular Filtration Rate in Patients with Type 2 Diabetes Mellitus: The REBOUND Study. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1174654
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174654