SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models
Joint Authors
Wang, Guixia
Cao, Yue
Yan, Zi
Zhou, Tong
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Type 2 diabetes mellitus is a complex age-related metabolic disease.
Cognitive dysfunction and learning and memory deficits are main characteristics of age-related metabolic diseases in the central nervous system.
The underlying mechanisms contributing to cognitive decline are complex, especially cognitive dysfunction associated with type 2 diabetes mellitus.
SIRT1, as one of the modulators in insulin resistance, is indispensable for learning and memory.
In the present study, deacetylation, oxidative stress, mitochondrial dysfunction, inflammation, microRNA, and tau phosphorylation are considered in the context of mechanism and significance of SIRT1 in learning and memory in diabetic and nondiabetic murine models.
In addition, future research directions in this field are discussed, including therapeutic potential of its activator, resveratrol, and application of other compounds in cognitive improvement.
Our findings suggest that SIRT1 might be a potential therapeutic target for the treatment of cognitive impairment induced by type 2 diabetes mellitus.
American Psychological Association (APA)
Cao, Yue& Yan, Zi& Zhou, Tong& Wang, Guixia. 2017. SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1174669
Modern Language Association (MLA)
Cao, Yue…[et al.]. SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models. Journal of Diabetes Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1174669
American Medical Association (AMA)
Cao, Yue& Yan, Zi& Zhou, Tong& Wang, Guixia. SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1174669
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174669