Comparative Pharmacokinetic Profiles of Puerarin in Rat Plasma by UHPLC-MSMS after Oral Administration of Pueraria lobata Extract and Pure Puerarin
Joint Authors
Zhang, Guozhe
Ji, Jianwei
Sun, Mingzhong
Ji, Yuqiao
Ji, Hongjian
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Puerarin is the main biologically active isoflavone in Pueraria lobata and has a wide range of biological activities.
However, due to its poor water solubility and low oral bioavailability, its clinical applications are restricted.
Compared with puerarin, the Pueraria lobata extract (PLE) has better water solubility, lower toxicity, and less side effects.
In this study, the pharmacokinetics of orally administered puerarin (100 mg/kg) and PLE (763 mg/kg, equivalent to 100.0 mg/kg of puerarin) to rats was investigated by the UHPLC-MS/MS method.
Results showed that when the rats were administered PLE, the area under the concentration-time curve from zero to infinity (AUC0-inf) dramatically increased from 219.83 ± 64.37 μg h/L to 462.62 ± 51.74 μg h/L (p<0.01).
The elimination half-time (t1/2) also increased from 1.60 ± 0.38 h to 12.04 ± 5.10 h (p<0.01).
The maximum concentration (Cmax) of puerarin decreased from 101.64 ± 41.82 ng/mL to 48.64 ± 21.47 ng/mL (p<0.01), and time to reach the maximum plasma concentration (Tmax) of puerarin decreased from 1.46 ± 1.08 h to 0.54 ± 0.30 h (p<0.01).
Results indicated that the pharmacokinetics of puerarin in Pueraria lobata may be dramatically different from pure puerarin in the plasma of rat, and oral bioavailability of puerarin may be increased when PLE was administrated to rats.
American Psychological Association (APA)
Zhang, Guozhe& Ji, Jianwei& Sun, Mingzhong& Ji, Yuqiao& Ji, Hongjian. 2020. Comparative Pharmacokinetic Profiles of Puerarin in Rat Plasma by UHPLC-MSMS after Oral Administration of Pueraria lobata Extract and Pure Puerarin. Journal of Analytical Methods in Chemistry،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1174748
Modern Language Association (MLA)
Zhang, Guozhe…[et al.]. Comparative Pharmacokinetic Profiles of Puerarin in Rat Plasma by UHPLC-MSMS after Oral Administration of Pueraria lobata Extract and Pure Puerarin. Journal of Analytical Methods in Chemistry No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1174748
American Medical Association (AMA)
Zhang, Guozhe& Ji, Jianwei& Sun, Mingzhong& Ji, Yuqiao& Ji, Hongjian. Comparative Pharmacokinetic Profiles of Puerarin in Rat Plasma by UHPLC-MSMS after Oral Administration of Pueraria lobata Extract and Pure Puerarin. Journal of Analytical Methods in Chemistry. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1174748
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174748