Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease
Joint Authors
Yang, Yu
Huang, Hui
Xu, Zheng
Duan, Jun-kai
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Diabetic kidney disease (DKD) is a widespread chronic microvascular complication of diabetes mellitus (DM), affects almost 30–50% of patients, and represents a leading cause of death of DM.
Serotonin or 5-hydroxytryptamine (5-HT) is a multifunctional bioamine that has crucial roles in many physiological pathways.
Recently, emerging evidence from experimental and clinical studies has demonstrated that 5-HT is involved in the pathogenesis of diabetic vascular complications.
The 5-HT receptor (5-HTR) antagonists exert renoprotective effects by suppressing oxidative stress, suggesting that 5-HTR can be used as a potential target for treating DKD.
In this review, therefore, we summarize the published information available for the involvement of 5-HT and 5-HTR antagonists in the pathogenesis of various diabetic complications with a particular focus of DKD.
We conclude that 5-HTR is a potential therapeutic target for treating DKD, as it has been successfully applied in animal models and has currently being investigated in randomized and controlled clinical trials.
American Psychological Association (APA)
Yang, Yu& Huang, Hui& Xu, Zheng& Duan, Jun-kai. 2017. Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1174767
Modern Language Association (MLA)
Yang, Yu…[et al.]. Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease. Journal of Diabetes Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1174767
American Medical Association (AMA)
Yang, Yu& Huang, Hui& Xu, Zheng& Duan, Jun-kai. Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1174767
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174767