Gene Expression Profiling Identifies Downregulation of the Neurotrophin-MAPK Signaling Pathway in Female Diabetic Peripheral Neuropathy Patients
Joint Authors
Xu, Jin
Ji, Lin-dan
Hu, Su-pei
Zhou, Mi
Feng, Mei
Luo, Lin
Zhou, Wen-Hua
Cai, Jiang-Jia
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM).
It is not diagnosed or managed properly in the majority of patients because its pathogenesis remains controversial.
In this study, human whole genome microarrays identified 2898 and 4493 differentially expressed genes (DEGs) in DM and DPN patients, respectively.
A further KEGG pathway analysis indicated that DPN and DM share four pathways, including apoptosis, B cell receptor signaling pathway, endocytosis, and Toll-like receptor signaling pathway.
The DEGs identified through comparison of DPN and DM were significantly enriched in MAPK signaling pathway, NOD-like receptor signaling pathway, and neurotrophin signaling pathway, while the “neurotrophin-MAPK signaling pathway” was notably downregulated.
Seven DEGs from the neurotrophin-MAPK signaling pathway were validated in additional 78 samples, and the results confirmed the initial microarray findings.
These findings demonstrated that downregulation of the neurotrophin-MAPK signaling pathway may be the major mechanism of DPN pathogenesis, thus providing a potential approach for DPN treatment.
American Psychological Association (APA)
Luo, Lin& Zhou, Wen-Hua& Cai, Jiang-Jia& Feng, Mei& Zhou, Mi& Hu, Su-pei…[et al.]. 2017. Gene Expression Profiling Identifies Downregulation of the Neurotrophin-MAPK Signaling Pathway in Female Diabetic Peripheral Neuropathy Patients. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1174806
Modern Language Association (MLA)
Luo, Lin…[et al.]. Gene Expression Profiling Identifies Downregulation of the Neurotrophin-MAPK Signaling Pathway in Female Diabetic Peripheral Neuropathy Patients. Journal of Diabetes Research No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1174806
American Medical Association (AMA)
Luo, Lin& Zhou, Wen-Hua& Cai, Jiang-Jia& Feng, Mei& Zhou, Mi& Hu, Su-pei…[et al.]. Gene Expression Profiling Identifies Downregulation of the Neurotrophin-MAPK Signaling Pathway in Female Diabetic Peripheral Neuropathy Patients. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1174806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174806