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Exercise Metabolism in Nonobese Patients with Type 2 Diabetes Following the Acute Restoration of Normoglycaemia
Joint Authors
Gaffney, Christopher J.
Mansell, Peter
Stephens, Francis B.
Macdonald, Ian A.
Tsintzas, Kostas
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study investigated how acute restoration of normoglycaemia affected energy metabolism during exercise in nonobese patients with type 2 diabetes.
Six subjects (mean ± SEM) aged 56.2 ± 2.7 years, with a BMI of 24.5 ± 1.5 kg/m2 and a VO2 peak of 28.7 ml/kg/min, attended the lab on two randomised occasions for a four-hour resting infusion of insulin or saline, followed by 30 minutes cycling at 50% VO2 peak.
During the 4 h resting infusion, there was a greater (P<0.0001) reduction in blood glucose in insulin treatment (INS) (from 11.2 ± 0.6 to 5.6 ± 0.1 mmol/l) than in saline treatment/control (CON) (from 11.5 ± 0.7 to 8.5 ± 0.6 mmol/l).
This was associated with a lower (P<0.05) resting metabolic rate in INS (3.87 ± 0.17) than in CON (4.39 ± 0.30 kJ/min).
During subsequent exercise, blood glucose increased significantly in INS from 5.6 ± 0.1 at 0 min to 6.3 ± 0.3 mmol/l at 30 min (P<0.01), which was accompanied by a lower blood lactate response (P<0.05).
Oxygen uptake, rates of substrate utilization, heart rate, and ratings of perceived exertion were not different between trials.
Insulin-induced normoglycaemia increased blood glucose during subsequent exercise without altering overall substrate utilization.
American Psychological Association (APA)
Gaffney, Christopher J.& Mansell, Peter& Stephens, Francis B.& Macdonald, Ian A.& Tsintzas, Kostas. 2017. Exercise Metabolism in Nonobese Patients with Type 2 Diabetes Following the Acute Restoration of Normoglycaemia. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1174831
Modern Language Association (MLA)
Gaffney, Christopher J.…[et al.]. Exercise Metabolism in Nonobese Patients with Type 2 Diabetes Following the Acute Restoration of Normoglycaemia. Journal of Diabetes Research No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1174831
American Medical Association (AMA)
Gaffney, Christopher J.& Mansell, Peter& Stephens, Francis B.& Macdonald, Ian A.& Tsintzas, Kostas. Exercise Metabolism in Nonobese Patients with Type 2 Diabetes Following the Acute Restoration of Normoglycaemia. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1174831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174831