Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 Diabetes
Joint Authors
Wang, Yufan
Yin, Yanhua
Ding, Xiaoying
Peng, Liang
Hou, Yanqiang
Ling, Yunxia
Gu, Mingyu
Sun, Haiyan
Peng, Yongde
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The objectives of the study were to investigate serum ANGPTL8 concentrations in different glucose metabolic statuses and to explore the correlations between serum ANGPTL8 levels and various metabolic parameters.
Serum ANGPTL8 levels were determined using ELISA in 22 subjects with NGT (normal glucose tolerance), 74 subjects with IGR (impaired glucose regulation), and 33 subjects with T2DM (type 2 diabetes mellitus).
Subjects with IFG, IGT, CGI, and T2DM had higher levels of serum ANGPTL8 than subjects with NGT.
Serum ANGPTL8 was positively correlated with FPG, fasting C-peptide, and postprandial C-peptide and negatively correlated with BETA/IR when adjusted for age and BMI.
Multivariate analysis suggested FPG and fasting C-peptide as independent factors associated with serum ANGPTL8 levels.
Serum ANGPTL8 concentrations were significantly increased in IGR and T2DM.
Serum ANGPTL8 might play a role in the pathological mechanism of glucose intolerance.
American Psychological Association (APA)
Yin, Yanhua& Ding, Xiaoying& Peng, Liang& Hou, Yanqiang& Ling, Yunxia& Gu, Mingyu…[et al.]. 2017. Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 Diabetes. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1174849
Modern Language Association (MLA)
Yin, Yanhua…[et al.]. Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 Diabetes. Journal of Diabetes Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1174849
American Medical Association (AMA)
Yin, Yanhua& Ding, Xiaoying& Peng, Liang& Hou, Yanqiang& Ling, Yunxia& Gu, Mingyu…[et al.]. Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 Diabetes. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1174849
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174849