Transcriptional Profile of Kidney from Type 2 Diabetic dbdb Mice
Joint Authors
Zhang, Haojun
Zhao, Tingting
Li, Ping
Yan, Meihua
Zhao, Hailing
Li, Zhiguo
Zhu, Bin
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Diabetic nephropathy (DN), a common diabetic microvascular complication, is characterized by progressive glomerular sclerosis and tubulointerstitial fibrosis.
However, the underlying mechanisms involved in DN remain to be elucidated.
We explored changes in the transcriptional profile in spontaneous type 2 diabetic db/db mice by using the cDNA microarray.
Compared with control db/m mice, the db/db mice exhibited marked increases in body weight, kidney weight, and urinary albumin excretion.
Renal histological analysis revealed mesangial expansion and thickness of the basement membrane in the kidney of the db/db mice.
A total of 355 differentially expressed genes (DEGs) were identified by microarray analysis.
Pathway enrichment analysis suggested that biological oxidation, bile acid metabolism, and steroid hormone synthesis were the 3 major significant pathways.
The top 10 hub genes were selected from the constructed PPI network of DEGs, including Ccnb2 and Nr1i2, which remained largely unclear in DN.
We believe that our study can help elucidate the molecular mechanisms underlying DN.
American Psychological Association (APA)
Zhang, Haojun& Zhao, Tingting& Li, Zhiguo& Yan, Meihua& Zhao, Hailing& Zhu, Bin…[et al.]. 2017. Transcriptional Profile of Kidney from Type 2 Diabetic dbdb Mice. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1174888
Modern Language Association (MLA)
Zhang, Haojun…[et al.]. Transcriptional Profile of Kidney from Type 2 Diabetic dbdb Mice. Journal of Diabetes Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1174888
American Medical Association (AMA)
Zhang, Haojun& Zhao, Tingting& Li, Zhiguo& Yan, Meihua& Zhao, Hailing& Zhu, Bin…[et al.]. Transcriptional Profile of Kidney from Type 2 Diabetic dbdb Mice. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1174888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174888