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Performance Optimization of Microvalves Based on a Microhole Array for Microfluidic Chips
Joint Authors
Xie, Yang
Sun, Cuimin
You, Hui
Xu, Ronald X.
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A microfluidic chip with a microvalve based on a microhole array is proposed in this paper for the POCT of tumor marker proteins.
In order to control the biochemical reaction time accurately and obtain a higher testing sensitivity, the parameters of the microhole array are optimized basing on the investigation of the effects of the variation of those parameters on the fluid rate and the residual liquid value in the microvalve region.
By conducting liquid flow experiments using microvalves based on microhole arrays with varying microstructural parameters, the residual rate of reaction products is demonstrated to be proportional to the depth and diameter of the microholes and inversely proportional to the distance between the microhole centers.
A comprehensive analysis indicates that a microhole depth of 95 μm, a microhole diameter of 230 μm, and a distance between microhole centers of 250 μm not only ensure a sufficiently long delay time, but also reduce the residual rate of reaction products, thereby providing an optimum microvalve performance that maximizes the detection efficiency and accuracy of microfluidic chips.
American Psychological Association (APA)
Sun, Cuimin& You, Hui& Xie, Yang& Xu, Ronald X.. 2020. Performance Optimization of Microvalves Based on a Microhole Array for Microfluidic Chips. Journal of Analytical Methods in Chemistry،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1174942
Modern Language Association (MLA)
Sun, Cuimin…[et al.]. Performance Optimization of Microvalves Based on a Microhole Array for Microfluidic Chips. Journal of Analytical Methods in Chemistry No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1174942
American Medical Association (AMA)
Sun, Cuimin& You, Hui& Xie, Yang& Xu, Ronald X.. Performance Optimization of Microvalves Based on a Microhole Array for Microfluidic Chips. Journal of Analytical Methods in Chemistry. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1174942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1174942