Near-Infrared Spectroscopy as a Process Analytical Technology Tool for Monitoring the Steaming Process of Gastrodiae rhizoma with Multiparameters and Chemometrics

Joint Authors

Zhang, Shengsheng
Zuo, Yamin
Deng, Xuehua
Wu, Qing
Yang, Jing
Li, Chen

Source

Journal of Analytical Methods in Chemistry

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-11-04

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Chemistry

Abstract EN

Steaming is a vital unit operation in traditional Chinese medicine (TCM), which greatly affects the active ingredients and the pharmacological efficacy of the products.

Near-infrared (NIR) spectroscopy has already been widely used as a strong process analytical technology (PAT) tool.

In this study, the potential usage of NIR spectroscopy to monitor the steaming process of Gastrodiae rhizoma was explored.

About 10 lab scale batches were employed to construct quantitative models to determine four chemical ingredients and moisture change during the steaming process.

Gastrodin, p-hydroxybenzyl alcohol, parishin B, and parishin A were modeled by different multivariate calibration models (SMLR and PLS), while the content of the moisture was modeled by principal component regression (PCR).

In the optimized models, the root mean square errors of prediction (RMSEP) for gastrodin, p-hydroxybenzyl alcohol, parishin B, parishin A, and moisture were 0.0181, 0.0143, 0.0132, 0.0244, and 2.15, respectively, and correlation coefficients (Rp2) were 0.9591, 0.9307, 0.9309, 0.9277, and 0.9201, respectively.

Three other batches’ results revealed that the accuracy of the model was acceptable and that was specific for next drying step.

In addition, the results demonstrated the method was reliable in process performance and robustness.

This method holds a great promise to replace current subjective color judgment and time-consuming HPLC or UV/Vis methods and is suitable for rapid online monitoring and quality control in the TCM industrial steaming process.

American Psychological Association (APA)

Zuo, Yamin& Yang, Jing& Li, Chen& Deng, Xuehua& Zhang, Shengsheng& Wu, Qing. 2020. Near-Infrared Spectroscopy as a Process Analytical Technology Tool for Monitoring the Steaming Process of Gastrodiae rhizoma with Multiparameters and Chemometrics. Journal of Analytical Methods in Chemistry،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1174947

Modern Language Association (MLA)

Yang, Jing…[et al.]. Near-Infrared Spectroscopy as a Process Analytical Technology Tool for Monitoring the Steaming Process of Gastrodiae rhizoma with Multiparameters and Chemometrics. Journal of Analytical Methods in Chemistry No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1174947

American Medical Association (AMA)

Zuo, Yamin& Yang, Jing& Li, Chen& Deng, Xuehua& Zhang, Shengsheng& Wu, Qing. Near-Infrared Spectroscopy as a Process Analytical Technology Tool for Monitoring the Steaming Process of Gastrodiae rhizoma with Multiparameters and Chemometrics. Journal of Analytical Methods in Chemistry. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1174947

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1174947