Hmox1 Deficiency Sensitizes Mice to Peroxynitrite Formation and Diabetic Glomerular Microvascular Injuries
Joint Authors
Lenoir, Olivia
Gaillard, François
Lazareth, Hélène
Robin, Blaise
Tharaux, Pierre-Louis
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
Indirect evidence suggests a role for heme oxygenase-1 (HO-1) in limiting diabetic vasculopathy.
The goal of this study was to assess the role of HO-1 in the development of microvascular lesions within glomeruli during diabetes mellitus using a mouse model with specific alteration of the Hmox1 gene.
Approach and Results.
The effects of Hmox1 haploinsufficiency were studied as a means of assessing the intrinsic contribution of HO-1 in the development of renal microvascular lesions during diabetes.
Renal function and histology were analyzed 10 weeks after diabetes induction with streptozotocin.
Diabetic Hmox1+/− mice showed higher levels of albuminuria and blood urea compared to their wild-type diabetic littermates.
More severe glomerular microvascular lesions were also observed in the diabetic Hmox1+/− mice.
This was associated with a renal increase in the expression of the oxidative stress marker, nitrotyrosine.
Conclusions.
Genetic Hmox1 partial deficiency is sufficient to sensitize mice to the development of diabetic glomerular microvascular lesions.
HO-1 exerts antioxidant effects in the kidney during diabetes mellitus.
These have protective effects on the development of glomerular endothelial injury.
American Psychological Association (APA)
Lenoir, Olivia& Gaillard, François& Lazareth, Hélène& Robin, Blaise& Tharaux, Pierre-Louis. 2017. Hmox1 Deficiency Sensitizes Mice to Peroxynitrite Formation and Diabetic Glomerular Microvascular Injuries. Journal of Diabetes Research،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1175035
Modern Language Association (MLA)
Lenoir, Olivia…[et al.]. Hmox1 Deficiency Sensitizes Mice to Peroxynitrite Formation and Diabetic Glomerular Microvascular Injuries. Journal of Diabetes Research No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1175035
American Medical Association (AMA)
Lenoir, Olivia& Gaillard, François& Lazareth, Hélène& Robin, Blaise& Tharaux, Pierre-Louis. Hmox1 Deficiency Sensitizes Mice to Peroxynitrite Formation and Diabetic Glomerular Microvascular Injuries. Journal of Diabetes Research. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1175035
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175035