Comparison of Rheological, Drug Release, and Mucoadhesive Characteristics upon Storage between Hydrogels with Unmodified or Beta-Glycerophosphate-Crosslinked Chitosan
Joint Authors
Szymańska, Emilia
Winnicka, Katarzyna
Czajkowska-Kośnik, Anna
Source
International Journal of Polymer Science
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The physicochemical characteristics of beta-glycerophosphate-crosslinked chitosan hydrogels were investigated upon long-term storage at ambient, accelerated, and refrigerated conditions and compared to unmodified chitosan formulations.
Additionally, the impact of chitosan modification on the ex vivo mucoadhesive performance in contact with porcine vaginal mucosa and on the drug release profile from hydrogels was evaluated.
Viscosity and mechanical properties of formulations with unmodified chitosan decreased significantly upon storage regardless of tested conditions as a result of hydrolytic depolymerization.
Introduction of ion crosslinker exerted stabilizing effect on physicochemical performance of chitosan hydrogels but only upon storage at refrigerated conditions.
Beta-glycerophosphate-modified chitosan formulations preserved organoleptic, rheological behavior, and hydrogel structure up to 3-month storage at 4 ± 2°C.
Viscosity variations upon storage influenced markedly mucoadhesive properties and drug release rate from hydrogels.
American Psychological Association (APA)
Szymańska, Emilia& Czajkowska-Kośnik, Anna& Winnicka, Katarzyna. 2018. Comparison of Rheological, Drug Release, and Mucoadhesive Characteristics upon Storage between Hydrogels with Unmodified or Beta-Glycerophosphate-Crosslinked Chitosan. International Journal of Polymer Science،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1175071
Modern Language Association (MLA)
Szymańska, Emilia…[et al.]. Comparison of Rheological, Drug Release, and Mucoadhesive Characteristics upon Storage between Hydrogels with Unmodified or Beta-Glycerophosphate-Crosslinked Chitosan. International Journal of Polymer Science No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1175071
American Medical Association (AMA)
Szymańska, Emilia& Czajkowska-Kośnik, Anna& Winnicka, Katarzyna. Comparison of Rheological, Drug Release, and Mucoadhesive Characteristics upon Storage between Hydrogels with Unmodified or Beta-Glycerophosphate-Crosslinked Chitosan. International Journal of Polymer Science. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1175071
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175071