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Electrochemotherapy: A Review of Current Status, Alternative IGP Approaches, and Future Perspectives
Joint Authors
Esmaeili, Nazila
Friebe, Michael
Source
Journal of Healthcare Engineering
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The efficiency of electroporation (EP) has made it a widely used therapeutic procedure to transfer cell killing substances effectively to the target site.
A lot of researches are being done on EP-based cancer treatment techniques.
Electrochemotherapy (ECT) is the first EP-based application in the field of drug administration.
ECT is a local and nonthermal treatment of cancer that combines the use of a medical device with pharmaceutical agents to obtain local tumor control in solid cancers.
It involves the application of eight, 100µs, pulses at 1 or 5000 Hz frequency and specified electric field (V/cm) with a median duration of 25 minutes.
The efficacy of chemotherapeutic drugs increases by applying short and intense electrical pulses.
Several clinical studies proposed ECT as a safe and complementary curative or palliative treatment option (curative intent of 50% to 63% in the treatment of Basal Cell Carcinoma (BCC)) to treat a number of solid tumors and skin malignancies, which are not suitable for conventional treatments.
It is used currently for treatment of cutaneous and subcutaneous lesions, without consideration of their histology.
On the contrary, it is also becoming a practical method for treatment of internal, deep-seated tumors and tissues.
A review of this method, needed instruments, alternative image-guided procedures (IGP) approaches, and future perspectives and recommendations are discussed in this paper.
American Psychological Association (APA)
Esmaeili, Nazila& Friebe, Michael. 2019. Electrochemotherapy: A Review of Current Status, Alternative IGP Approaches, and Future Perspectives. Journal of Healthcare Engineering،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1175099
Modern Language Association (MLA)
Esmaeili, Nazila& Friebe, Michael. Electrochemotherapy: A Review of Current Status, Alternative IGP Approaches, and Future Perspectives. Journal of Healthcare Engineering No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1175099
American Medical Association (AMA)
Esmaeili, Nazila& Friebe, Michael. Electrochemotherapy: A Review of Current Status, Alternative IGP Approaches, and Future Perspectives. Journal of Healthcare Engineering. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1175099
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175099