Low Vitamin D and Its Association with Cognitive Impairment and Dementia
Joint Authors
Sultan, Sadia
Taimuri, Uzma
Basnan, Shatha Abdulrzzaq
Ai-Orabi, Waad Khalid
Awadallah, Afaf
Almowald, Fatimah
Hazazi, Amira
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-30
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Vitamin D is a neurosteroid hormone that regulates neurotransmitters and neurotrophins.
It has anti-inflammatory, antioxidant, and neuroprotective properties.
It increases neurotrophic factors such as nerve growth factor which further promotes brain health.
Moreover, it is also helpful in the prevention of amyloid accumulation and promotes amyloid clearance.
Emerging evidence suggests its role in the reduction of Alzheimer’s disease hallmarks such as amyloid-beta and phosphorylated tau.
Many preclinical studies have supported the hypothesis that vitamin D leads to attentional, behavioral problems and cognitive impairment.
Cross-sectional studies have consistently found that vitamin D levels are significantly low in individuals with Alzheimer’s disease and cognitive impairment compared to healthy adults.
Longitudinal studies and meta-analysis have also exhibited an association of low vitamin D with cognitive impairment and Alzheimer’s disease.
Despite such evidence, the causal association cannot be sufficiently answered.
In contrast to observational studies, findings from interventional studies have produced mixed results on the role of vitamin D supplementation in the prevention and treatment of cognitive impairment and dementia.
The biggest issue of the existing RCTs is their small sample size, lack of consensus over the dose, and age of initiation of vitamin D supplements to prevent cognitive impairment.
Therefore, there is a need for large double-blind randomized control trials to assess the benefits of vitamin D supplementation in the prevention and treatment of cognitive impairment.
American Psychological Association (APA)
Sultan, Sadia& Taimuri, Uzma& Basnan, Shatha Abdulrzzaq& Ai-Orabi, Waad Khalid& Awadallah, Afaf& Almowald, Fatimah…[et al.]. 2020. Low Vitamin D and Its Association with Cognitive Impairment and Dementia. Journal of Aging Research،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1175110
Modern Language Association (MLA)
Sultan, Sadia…[et al.]. Low Vitamin D and Its Association with Cognitive Impairment and Dementia. Journal of Aging Research No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1175110
American Medical Association (AMA)
Sultan, Sadia& Taimuri, Uzma& Basnan, Shatha Abdulrzzaq& Ai-Orabi, Waad Khalid& Awadallah, Afaf& Almowald, Fatimah…[et al.]. Low Vitamin D and Its Association with Cognitive Impairment and Dementia. Journal of Aging Research. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1175110
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175110