Structural Characterization, Antioxidant Activity, and Biomedical Application of Astragalus Polysaccharide Degradation Products
Joint Authors
Ouyang, Jian-Ming
Sun, Xin-Yuan
Wang, Jian-Min
Source
International Journal of Polymer Science
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
To study the antioxidant capacity of Astragalus polysaccharides (APS) with different molecular weights, we used hydrogen peroxide to degrade original Astragalus polysaccharide (APS0) with an initial molecular weight of 11.03 kDa and obtained three degraded polysaccharides with molecular weights of 8.38 (APS1), 4.72 (APS2), and 2.60 kDa (APS3).
The structures of these polysaccharides were characterized by 1H NMR, 13C NMR, FT-IR, and GC/MS.
The degradation process did not cause significant changes in the main chain structure of APS.
The monosaccharide component of APS before and after degradation was slightly changed.
The antioxidant ability in vitro (removing hydroxyl and ABTS radicals and reducing ability) and in cells (superoxide dismutase and malondialdehyde generation) of these polysaccharides is closely related to their molecular weight.
If the molecular weight of APS is very high or low, it is not conducive to their activity.
Only APS2 with moderate molecular weight showed the greatest antioxidant activity and ability to repair human kidney epithelial (HK-2) cells.
Therefore, APS2 can be used as a potential antistone polysaccharide drug.
American Psychological Association (APA)
Wang, Jian-Min& Sun, Xin-Yuan& Ouyang, Jian-Ming. 2018. Structural Characterization, Antioxidant Activity, and Biomedical Application of Astragalus Polysaccharide Degradation Products. International Journal of Polymer Science،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1175156
Modern Language Association (MLA)
Wang, Jian-Min…[et al.]. Structural Characterization, Antioxidant Activity, and Biomedical Application of Astragalus Polysaccharide Degradation Products. International Journal of Polymer Science No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1175156
American Medical Association (AMA)
Wang, Jian-Min& Sun, Xin-Yuan& Ouyang, Jian-Ming. Structural Characterization, Antioxidant Activity, and Biomedical Application of Astragalus Polysaccharide Degradation Products. International Journal of Polymer Science. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1175156
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175156