Application of 3D Printing Technology for Design and Manufacturing of Customized Components for a Mechanical Stretching Bioreactor
Joint Authors
Meglio, Franca Di
Castaldo, Clotilde
Putame, Giovanni
Terzini, Mara
Carbonaro, Dario
Pisani, Giuseppe
Serino, Gianpaolo
Massai, Diana
Source
Journal of Healthcare Engineering
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Three-dimensional (3D) printing represents a key technology for rapid prototyping, allowing easy, rapid, and low-cost fabrication.
In this work, 3D printing was applied for the in-house production of customized components of a mechanical stretching bioreactor with potential application for cardiac tissue engineering and mechanobiology studies.
The culture chamber housing and the motor housing were developed as functional permanent parts, aimed at fixing the culture chamber position and at guaranteeing motor watertightness, respectively.
Innovative sample holder prototypes were specifically designed and 3D-printed for holding thin and soft biological samples during cyclic stretch culture.
The manufactured components were tested in-house and in a cell biology laboratory.
Moreover, tensile tests and finite element analysis were performed to investigate the gripping performance of the sample holder prototypes.
All the components showed suitable performances in terms of design, ease of use, and functionality.
Based on 3D printing, the bioreactor optimization was completely performed in-house, from design to fabrication, enabling customization freedom, strict design-to-prototype timing, and cost and time effective testing, finally boosting the bioreactor development process.
American Psychological Association (APA)
Putame, Giovanni& Terzini, Mara& Carbonaro, Dario& Pisani, Giuseppe& Serino, Gianpaolo& Meglio, Franca Di…[et al.]. 2019. Application of 3D Printing Technology for Design and Manufacturing of Customized Components for a Mechanical Stretching Bioreactor. Journal of Healthcare Engineering،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1175164
Modern Language Association (MLA)
Putame, Giovanni…[et al.]. Application of 3D Printing Technology for Design and Manufacturing of Customized Components for a Mechanical Stretching Bioreactor. Journal of Healthcare Engineering No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1175164
American Medical Association (AMA)
Putame, Giovanni& Terzini, Mara& Carbonaro, Dario& Pisani, Giuseppe& Serino, Gianpaolo& Meglio, Franca Di…[et al.]. Application of 3D Printing Technology for Design and Manufacturing of Customized Components for a Mechanical Stretching Bioreactor. Journal of Healthcare Engineering. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1175164
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175164