New 1,2,3-Triazole Containing Polyesters via Click Step-Growth Polymerization and Nanoparticles Made of Them
Joint Authors
Kantaria, Tengiz
Kantaria, Temur
Titvinidze, Giorgi
Otinashvili, Giuli
Kupatadze, Nino
Zavradashvili, Nino
Tugushi, David
Katsarava, Ramaz
Source
International Journal of Polymer Science
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
High-molecular-weight AA-BB-type aliphatic polyesters were synthesized via Cu(I)-catalyzed click step-growth polymerization (SGP) following a new synthetic strategy.
The synthesis was performed between diyne and diazide monomers in an organic solvent as one pot process using three components and two stages.
The dipropargyl esters of dicarboxylic acids (component 1) were used as diyne monomers, di-(bromoacetic acid)-alkylene diesters (component 2) were used as precursors of diazide monomers, and sodium azide (component 3) was used for generating diazide monomers.
The SGP was carried out in two steps: at Step 1 dibromoacetates interacted with two moles of sodium azide resulting in diazide monomers which interacted in situ with diyne monomers at Step 2 in the presence of Cu(I) catalyst.
A systematic study was done for optimizing the multiparameter click SGP in terms of the solvent, duration of both Step 1 and Step 2, solution concentration, catalyst concentration, catalyst and catalyst activator (ligand) nature, catalyst/ligand mole ratio, and temperature of both steps of the click SGP.
As a result, high-molecular-weight (MW up to 74 kDa) elastic film-forming click polyesters were obtained.
The new polymers were found suitable for fabricating biodegradable nanoparticles, which are promising as drug delivery containers in nanotherapy.
American Psychological Association (APA)
Kantaria, Tengiz& Kantaria, Temur& Titvinidze, Giorgi& Otinashvili, Giuli& Kupatadze, Nino& Zavradashvili, Nino…[et al.]. 2018. New 1,2,3-Triazole Containing Polyesters via Click Step-Growth Polymerization and Nanoparticles Made of Them. International Journal of Polymer Science،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1175216
Modern Language Association (MLA)
Kantaria, Tengiz…[et al.]. New 1,2,3-Triazole Containing Polyesters via Click Step-Growth Polymerization and Nanoparticles Made of Them. International Journal of Polymer Science No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1175216
American Medical Association (AMA)
Kantaria, Tengiz& Kantaria, Temur& Titvinidze, Giorgi& Otinashvili, Giuli& Kupatadze, Nino& Zavradashvili, Nino…[et al.]. New 1,2,3-Triazole Containing Polyesters via Click Step-Growth Polymerization and Nanoparticles Made of Them. International Journal of Polymer Science. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1175216
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175216