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AC-CUTE: An Open-Label Study to Evaluate Progression of Structural Joint Damage and Inflammation in Subjects with Moderate to Severe Rheumatoid Arthritis
Joint Authors
Griffiths, Hedley
Bird, Paul
Peterfy, Charles
Countryman, Peter
Barrett, Rina
Youssef, Peter
Joshua, Fredrick
Hall, Stephen
Source
International Journal of Rheumatology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aim.
Examine the efficacy of once-weekly subcutaneous tocilizumab (SC-TCZ) on joint damage at 24 weeks based on radiography of the hands and feet and magnetic resonance imaging (MRI) of the hand in subjects with moderate to severe rheumatoid arthritis (RA).
Methods.
In this Australian open-label, multicentre, prospective, single-arm study, subjects received 162 mg SC-TCZ weekly.
Primary endpoint was change in radiographic Genant-modified Total Sharp Score (TSS) between baseline and Week 24.
Secondary endpoints included change from baseline to Week 24 in RA MRI scoring (RAMRIS) of erosions, synovitis, and osteitis and Cartilage Loss Score (CARLOS) in the dominant hand and disease activity score 28 (DAS28).
Results.
52 subjects were enrolled (80% female, mean (SD) age 57 (12) years).
Radiography showed mild but not significant progression of joint damage (mean (SD) change in TSS 0.46 (1.29)).
Synovitis reduced significantly on MRI; however, osteitis, erosion, and cartilage loss did not change significantly.
DAS28 improved significantly by Week 24; 78% of subjects achieved DAS28 remission.
SC-TCZ was generally well tolerated.
Conclusion.
Synovitis and DAS28 decreased significantly; however, no significant change in osteitis or joint damage was observed at Week 24.
Trial registration.
This trial is registered with Clinicaltrials.gov registration number NCT01951170 (ML28703).
American Psychological Association (APA)
Bird, Paul& Peterfy, Charles& Countryman, Peter& Griffiths, Hedley& Barrett, Rina& Youssef, Peter…[et al.]. 2018. AC-CUTE: An Open-Label Study to Evaluate Progression of Structural Joint Damage and Inflammation in Subjects with Moderate to Severe Rheumatoid Arthritis. International Journal of Rheumatology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1175490
Modern Language Association (MLA)
Bird, Paul…[et al.]. AC-CUTE: An Open-Label Study to Evaluate Progression of Structural Joint Damage and Inflammation in Subjects with Moderate to Severe Rheumatoid Arthritis. International Journal of Rheumatology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1175490
American Medical Association (AMA)
Bird, Paul& Peterfy, Charles& Countryman, Peter& Griffiths, Hedley& Barrett, Rina& Youssef, Peter…[et al.]. AC-CUTE: An Open-Label Study to Evaluate Progression of Structural Joint Damage and Inflammation in Subjects with Moderate to Severe Rheumatoid Arthritis. International Journal of Rheumatology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1175490
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175490