Cervical Cancer Cells Express Markers Associated with Immunosurveillance
Joint Authors
Valle-Mendiola, Arturo
Gutiérrez-Hoya, Adriana
Weiss-Steider, Benny
Soto-Cruz, Isabel
López-Santiago, Rubén
Zerecero-Carreón, Octavio
Moreno-Lafont, Martha
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cervical cancer is the second most frequent cancer in women in Mexico, and its development depends on the presence of human papillomaviruses in the uterine cervix.
These oncogenic viruses transform cells where the control over cell cycle disappears, and the capacity to induce apoptosis is absent.
On the other hand, some mutations confer to the transformed cells the ability to evade recognition by the immune system.
The expression of markers of the immune system such as CD95, MICA/B, CD39, CD73, NKp30, NKp46, CD44, CD24, NKG2A, and CTLA-4 was analysed by flow cytometry on cervical cancer cells INBL (HPV 18, stage IVB), HeLa (HPV 18), CaSki (HPV 16), and C33A (HPV-).
Our results showed the presence of atypical markers on cervical cancer cells; some of them are molecules involved in tumour cell recognition such as MICA/B and CD95.
Other markers associated with immune system escape, such as CD39, CD73, and CTLA-4, were also present.
Furthermore, we found that some cervical cancer cells expressed typical markers of NK cells like NKp30, NKp46, NKG2A, and KIR3DL1.
It is not clear whether these molecules confer any gain to the tumour cells or if they represent a disadvantage, but we hypothesise that these molecules that are present in cervical cancer cells allow them to mimic in front of the immune system.
American Psychological Association (APA)
Gutiérrez-Hoya, Adriana& Zerecero-Carreón, Octavio& Valle-Mendiola, Arturo& Moreno-Lafont, Martha& López-Santiago, Rubén& Weiss-Steider, Benny…[et al.]. 2019. Cervical Cancer Cells Express Markers Associated with Immunosurveillance. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1175650
Modern Language Association (MLA)
Gutiérrez-Hoya, Adriana…[et al.]. Cervical Cancer Cells Express Markers Associated with Immunosurveillance. Journal of Immunology Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1175650
American Medical Association (AMA)
Gutiérrez-Hoya, Adriana& Zerecero-Carreón, Octavio& Valle-Mendiola, Arturo& Moreno-Lafont, Martha& López-Santiago, Rubén& Weiss-Steider, Benny…[et al.]. Cervical Cancer Cells Express Markers Associated with Immunosurveillance. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1175650
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175650