Decreased Frequencies of Th17 and Tc17 Cells in Patients Infected with Avian Influenza A (H7N9) Virus
Joint Authors
Huang, Li
Zheng, Shufa
Cui, Dawei
Bao, Jiaqi
Wang, Xiaochen
Zou, Qianda
Zhao, Dejian
Yu, Fei
Dong, Yuejiao
Yang, Xianzhi
Xie, Guoliang
Chen, Weizhen
Chen, Yu
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The outbreak of avian influenza A (H7N9) virus infection, with a high mortality rate, has caused concern worldwide.
Although interleukin-17- (IL-17-) secreting CD4+ T (Th17) and CD8+ T (Tc17) cells have been proven to play crucial roles in influenza virus infection, the changes and roles of Th17 and Tc17 cells in immune responses to H7N9 infection remain controversial.
In this study, we found that the frequencies of Th17 and Tc17 cells among human peripheral blood mononuclear cells (PBMCs) as well as IL-17A protein and mRNA levels were markedly decreased in patients with acute H7N9 virus infection.
A positive correlation was found between the serum IL-17A level and the frequency of these two cell groups.
In vitro infection experiments revealed decreased Th17 and Tc17 cell frequency and IL-17A levels at various time points postinfection.
In addition, Th17 cells were the predominant sources of IL-17A in PBMCs of patients infected with H7N9 virus.
Taken together, our results indicate immune disorder in acute H7N9 infection and a restored Th17 and Tc17 cell frequency might serve as a biomarker for predicting recovery in patients infected with this virus.
American Psychological Association (APA)
Bao, Jiaqi& Cui, Dawei& Wang, Xiaochen& Zou, Qianda& Zhao, Dejian& Zheng, Shufa…[et al.]. 2019. Decreased Frequencies of Th17 and Tc17 Cells in Patients Infected with Avian Influenza A (H7N9) Virus. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1175682
Modern Language Association (MLA)
Bao, Jiaqi…[et al.]. Decreased Frequencies of Th17 and Tc17 Cells in Patients Infected with Avian Influenza A (H7N9) Virus. Journal of Immunology Research No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1175682
American Medical Association (AMA)
Bao, Jiaqi& Cui, Dawei& Wang, Xiaochen& Zou, Qianda& Zhao, Dejian& Zheng, Shufa…[et al.]. Decreased Frequencies of Th17 and Tc17 Cells in Patients Infected with Avian Influenza A (H7N9) Virus. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1175682
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175682