Granulosa Cell Tumor of the Ovary: A Retrospective Study of 31 Cases and a Review of the Literature
Joint Authors
Dridi, Manel
Chraiet, Nesrine
Batti, Rim
Ayadi, Mouna
Mokrani, Amina
Meddeb, Khedija
Yahiaoui, Yosra
Raies, Henda
Mezlini, Amel
Source
International Journal of Surgical Oncology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-29
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Adult granulosa cell tumors (AGCTs) are the most common sex cord-stromal tumors.
Unlike epithelial ovarian tumors, they occur in young women and are usually detected at an early stage.
The aim of this study was to report the clinical and pathological characteristics of AGCT patients and to identify the prognostic factors.
Methods.
All cases of AGCTs, treated at Salah Azaïz Institute between 1995 and 2010, were retrospectively included.
Kaplan-Meier’s statistical method was used to assess the relapse-free survival and the overall survival.
Results.
The final cohort included 31 patients with AGCT.
The mean age was 53 years (35–73 years).
Patients mainly presented with abdominal mass and/or pain (61%, n=19).
Mean tumor size was 20 cm.
The majority of patients had a stage I disease (61%, n=19).
Two among 3 patients with stage IV disease had liver metastasis.
Mitotic index was low in 45% of cases (n=14).
Surgical treatment was optimal in almost all cases (90%, n=28).
The median follow-up time was 14 years (1–184 months).
Ten patients relapsed (32%) with a median RFS of 8.4 years (6.8–9.9 years).
Mean overall survival was 13 years (11–15 years).
Stage I disease and low-to-intermediate mitotic index were associated with a better prognosis in univariate analysis (resp., p=0.05 and p=0.02) but were not independent prognostic factors.
Conclusion.
GCTs have a long natural history with common late relapses.
Hence, long active follow-up is recommended.
In Tunisian patients, hepatic metastases were more frequent than occidental series.
The prognosis remains good and initial staging at diagnosis is an important prognostic factor.
American Psychological Association (APA)
Dridi, Manel& Chraiet, Nesrine& Batti, Rim& Ayadi, Mouna& Mokrani, Amina& Meddeb, Khedija…[et al.]. 2018. Granulosa Cell Tumor of the Ovary: A Retrospective Study of 31 Cases and a Review of the Literature. International Journal of Surgical Oncology،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1175689
Modern Language Association (MLA)
Dridi, Manel…[et al.]. Granulosa Cell Tumor of the Ovary: A Retrospective Study of 31 Cases and a Review of the Literature. International Journal of Surgical Oncology No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1175689
American Medical Association (AMA)
Dridi, Manel& Chraiet, Nesrine& Batti, Rim& Ayadi, Mouna& Mokrani, Amina& Meddeb, Khedija…[et al.]. Granulosa Cell Tumor of the Ovary: A Retrospective Study of 31 Cases and a Review of the Literature. International Journal of Surgical Oncology. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1175689
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175689