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Interaction between IL-33 Gene Polymorphisms and Current Smoking with Susceptibility to Systemic Lupus Erythematosus
Joint Authors
Zhu, Xiaohua
Xie, Lin
Qin, Haihong
Liang, Jun
Yang, Yongsheng
Xu, Jinhua
Zhang, Tiejun
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aims.
This study is aimed at exploring the relation between IL-33 single-nucleotide polymorphisms (SNPs) and the risk of systemic lupus erythematosus (SLE).
Methods.
SNPStats (online software) was used to test the Hardy-Weinberg equilibrium in controls.
Generalized multifactor dimensionality reduction (GMDR) was adopted to screen the preferable interaction between IL-33 SNPs and current smoking.
Results.
Logistic regression analysis based on the fundamental data of age, gender, BMI, current smoking, and alcohol drinking showed that both rs1929992-G and rs1891385-C alleles were correlated with an increasing risk of SLE, the ORs (95% CI) of which were 1.62 (1.21-2.05) and 1.64 (1.22-2.10), respectively.
One two-locus model (rs1929992×current smoking) had a testing accuracy of 60.11% (P=0.0010).
Through an overall multidimensional model, optimum cross-validation consistency was obtained.
The analysis indicated that current smoking status influenced the SLE risk depending on the genotypes at rs1929992.
Pairwise LD analysis indicated that haplotype rs1929992G-rs7044343T was statistically related to the elevating risk of SLE (P<0.05).
Those subjects with the G-T haplotype had a higher SLE risk than those with other haplotypes, after correction with factors, including gender, alcohol drinking, age, BMI, and current smoking.
Conclusions.
The rs1929992-G and rs1891385-C allele, interaction between the rs1929992 gene and current smoking, and haplotype rs1929992G-rs7044343T were all risk factors of SLE.
American Psychological Association (APA)
Zhu, Xiaohua& Xie, Lin& Qin, Haihong& Liang, Jun& Yang, Yongsheng& Xu, Jinhua…[et al.]. 2019. Interaction between IL-33 Gene Polymorphisms and Current Smoking with Susceptibility to Systemic Lupus Erythematosus. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1175700
Modern Language Association (MLA)
Zhu, Xiaohua…[et al.]. Interaction between IL-33 Gene Polymorphisms and Current Smoking with Susceptibility to Systemic Lupus Erythematosus. Journal of Immunology Research No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1175700
American Medical Association (AMA)
Zhu, Xiaohua& Xie, Lin& Qin, Haihong& Liang, Jun& Yang, Yongsheng& Xu, Jinhua…[et al.]. Interaction between IL-33 Gene Polymorphisms and Current Smoking with Susceptibility to Systemic Lupus Erythematosus. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1175700
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175700