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pDC Activation by TLR78 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG
Joint Authors
Chen, Jingtao
Wu, Jing
Li, Shuang
Li, Tete
Lv, Xinping
Zhang, Mingyou
Zang, Guoxia
Qi, Chong
Liu, Yong-Jun
Xu, Liang
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Plasmacytoid dendritic cells (pDCs) express high levels of the toll-like receptors (TLRs) TLR7 and TLR9.
In response to TLR7 and TLR9 ligands, pDCs are primary producers of type I interferons.
Our previous study demonstrated that pDCs activated by the TLR7 ligand imiquimod (IMQ) and the TLR9 ligand CpG A can kill breast cancer cells in vitro and inhibit tumor growth in vivo.
Moreover, we observed a distinctive morphological, phenotypic change in pDCs after activation by IMQ and CpG A.
However, the effect of other TLR7 and TLR9 ligands on pDCs remains less understood.
In this study, we treat pDCs with the TLR7 ligand IMQ, TLR7/8 ligands (CL097 and CL075), and three TLR9 ligands (different types of CpGs).
The size of pDCs increased significantly after activation by TLR7, or TLR7/8 ligands.
TLR7, TLR7/8, and TLR9 ligands similarly modulated cytokine release, as well as protein expression of pDC markers, costimulatory molecules, and cytotoxic molecules.
Interestingly, TLR7/8 ligands, especially CL097, induced stronger responses.
These results are relevant to the further study of the role and mechanism of pDC-induced antitumor effects and may aid in the development of a new strategy for future tumor immunotherapy.
American Psychological Association (APA)
Wu, Jing& Li, Shuang& Li, Tete& Lv, Xinping& Zhang, Mingyou& Zang, Guoxia…[et al.]. 2019. pDC Activation by TLR78 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1175726
Modern Language Association (MLA)
Wu, Jing…[et al.]. pDC Activation by TLR78 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG. Journal of Immunology Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1175726
American Medical Association (AMA)
Wu, Jing& Li, Shuang& Li, Tete& Lv, Xinping& Zhang, Mingyou& Zang, Guoxia…[et al.]. pDC Activation by TLR78 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1175726
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175726