Enhancement of the Soluble Form of OX40 and OX40L Costimulatory Molecules but Reduction of the Membrane Form in Type 1 Diabetes (T1D)
Joint Authors
Li, Sicheng
An, Jingnan
Ding, Sisi
Sun, Lili
Chang, Xin
Huang, Ziyi
Zhou, Bin
Fang, Chen
Zhang, XueGuang
Liu, CuiPing
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This study analyzed the expression of membrane OX40 and OX40L (mOX40 and mOX40L) and levels of soluble OX40 and OX40L (sOX40 and sOX40L) in T1D patients to determine their clinical significance.
Peripheral blood (PB) was collected from patients with T1D and healthy control participants.
Expression of mOX40 and mOX40L on immune cells was detected by flow cytometry.
Levels of sOX40 and sOX40L in sera were measured by ELISA.
We demonstrated for the first time enhanced sOX40 and sOX40L expression and reduced mOX40 and mOX40L levels in T1D patients which correlated with the clinical characteristics and inflammatory factors.
These results suggest that OX40/OX40L signal may be promising biomarkers and associated with the pathogenesis of T1D.
American Psychological Association (APA)
An, Jingnan& Ding, Sisi& Li, Sicheng& Sun, Lili& Chang, Xin& Huang, Ziyi…[et al.]. 2019. Enhancement of the Soluble Form of OX40 and OX40L Costimulatory Molecules but Reduction of the Membrane Form in Type 1 Diabetes (T1D). Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1175732
Modern Language Association (MLA)
An, Jingnan…[et al.]. Enhancement of the Soluble Form of OX40 and OX40L Costimulatory Molecules but Reduction of the Membrane Form in Type 1 Diabetes (T1D). Journal of Immunology Research No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1175732
American Medical Association (AMA)
An, Jingnan& Ding, Sisi& Li, Sicheng& Sun, Lili& Chang, Xin& Huang, Ziyi…[et al.]. Enhancement of the Soluble Form of OX40 and OX40L Costimulatory Molecules but Reduction of the Membrane Form in Type 1 Diabetes (T1D). Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1175732
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175732
