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Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats
Joint Authors
Fernandes, Ana Angélica Henrique
Kaga, Anderson Kiyoshi
Barbanera, Pedro Octavio
Carmo, Nágilla Orleanne Lima do
Rosa, Lucas Rodolfo de Oliveira
Source
International Journal of Vascular Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Type 1 diabetes mellitus (T1DM) is characterized by insulin-deficient production leading to hyperglycemia, which is associated with diabetic complications such as cardiovascular diseases.
Antioxidants have been proving a good alternative to diabetic complications, with N-acetylcysteine (NAC) having antioxidant characteristics.
The aim of this study was to assess the effect of NAC on the lipid profile and the atherogenic index (AI) in streptozotocin- (STZ-) induced diabetic rats.
Method.
32 male Wistar rats (60 days of age) weighting ±250 g were randomly distributed into four groups (n=8): CTRL: control rats; CTRL+NAC: control rats treated with NAC; DM: diabetic rats; DM+NAC: diabetic rats treated with NAC.
T1DM was induced using STZ (60 mg/kg, ip; single dose), and NAC (25 mg/kg/day) was administrated by gavage, for 37 days.
The animals received chow and water ad libitum.
After the experimental period, blood and cardiac tissue samples were collected to analyze energetic metabolism, lipid profile, and AI.
Results.
NAC decreased (p<0.01) glycemia, energy intake, carbohydrate, and protein consumption in diabetic rats (DM+NAC), when compared with DM, while the alimentary efficiency was improved (p<0.01) in treated diabetic rats (DM+NAC).
Diabetic rats treated with NAC decreased (p<0.01) lipid profile and AI in diabetic rats (DM+NAC) when compared to DM.
Conclusion.
NAC improves lipid profile and decreases AI in STZ-induced diabetic rats.
American Psychological Association (APA)
Kaga, Anderson Kiyoshi& Barbanera, Pedro Octavio& Carmo, Nágilla Orleanne Lima do& Rosa, Lucas Rodolfo de Oliveira& Fernandes, Ana Angélica Henrique. 2018. Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats. International Journal of Vascular Medicine،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1175781
Modern Language Association (MLA)
Kaga, Anderson Kiyoshi…[et al.]. Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats. International Journal of Vascular Medicine No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1175781
American Medical Association (AMA)
Kaga, Anderson Kiyoshi& Barbanera, Pedro Octavio& Carmo, Nágilla Orleanne Lima do& Rosa, Lucas Rodolfo de Oliveira& Fernandes, Ana Angélica Henrique. Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats. International Journal of Vascular Medicine. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1175781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175781