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Impact of SNPsHaplotypes of IL10 and IFNG on the Development of Diffuse Large B-Cell Lymphoma
Joint Authors
Marangon, Amanda Vansan
Visentainer, Jeane Eliete Laguila
Cardozo, Daniela Maria
Marques, Silvia Barbosa Dutra
Guimarães, Fernando
Sell, Ana M.
Colli, Cristiane Maria
Lieber, Sophia Rocha
Aranha, Francisco José Penteado
Zulli, Roberto
de Souza, Victor Hugo
De Souza, Cármino Antonio
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The purpose of this study was to assess the influence of single-nucleotide polymorphisms (SNPs) on cytokine genes in the development of diffuse large B-cell lymphoma (DLBCL).
One hundred and twelve patients and 221 controls were investigated.
Among them, 97 patients treated with R-CHOP were subdivided into two groups: (i) complete remission of the disease and (ii) patients who progressed to death, relapsed, or had disease progression.
The SNPs investigated by PCR-SSP were TNF -308G>A (rs1800629), IFNG +874A>T (rs2430561), IL6 -174G>C (rs1800795), IL10 -1082A>G (rs1800896), IL10 -819C>T (rs1800871), IL10 -592C>A (rs1800872), and TGFB1 codon10T>C (rs1982073) and codon25G>C (rs1800471).
In general, the genotypes that have been associated in the literature with lower production or intermediate production of IL-10 and higher production of IFN-γ were associated with the protection of the development of the disease, possibly favoring the Th1 immune response and diminishing the capacity of cell proliferation.
However, patients receiving R-CHOP treatment presented unfavorable prognoses in the presence of genotypes related to the intermediate production of IL-10 and high production of TGF-β1, indicating that cytokines may be related to the response to treatment and action mechanisms of Rituximab.
American Psychological Association (APA)
Marangon, Amanda Vansan& Colli, Cristiane Maria& Cardozo, Daniela Maria& Visentainer, Jeane Eliete Laguila& Sell, Ana M.& Guimarães, Fernando…[et al.]. 2019. Impact of SNPsHaplotypes of IL10 and IFNG on the Development of Diffuse Large B-Cell Lymphoma. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1175821
Modern Language Association (MLA)
Marangon, Amanda Vansan…[et al.]. Impact of SNPsHaplotypes of IL10 and IFNG on the Development of Diffuse Large B-Cell Lymphoma. Journal of Immunology Research No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1175821
American Medical Association (AMA)
Marangon, Amanda Vansan& Colli, Cristiane Maria& Cardozo, Daniela Maria& Visentainer, Jeane Eliete Laguila& Sell, Ana M.& Guimarães, Fernando…[et al.]. Impact of SNPsHaplotypes of IL10 and IFNG on the Development of Diffuse Large B-Cell Lymphoma. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1175821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175821