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3β-Acetyloxy-oleanolic Acid Attenuates Pristane-Induced Lupus Nephritis by Regulating Th17 Differentiation
Joint Authors
Yu, Bolan
Huang, Zhaofeng
Zhao, Qingyu
Zhou, Xiaoqing
Chen, Huanpeng
Wei, Fengjiao
Su, Qiao
Liang, Jinhao
Yin, Meng
Tian, Xuyan
Liu, Zhonghua
Bai, Chuan
He, Xixin
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Th17 activity has been implicated in systemic lupus erythematosus (SLE), which is a systemic autoimmune disease with a typical clinical manifestation of lupus nephritis (LN).
Retinoic acid receptor-related orphan receptor gamma t (RORγt) has been shown to be important for Th17 differentiation.
In this study, we evaluated the inhibition of RORγt activity by 3β-acetyloxy-oleanolic acid (AOA), a small molecule isolated from the root of Symplocos laurina, a traditional herb belonging to South China.
We demonstrated that AOA can inhibit RORγt activity and prevent SLE pathogenesis in a pristane-induced LN model.
The results showed that AOA decreased RORγt transcription activity in a reporter assay and prevented Th17 differentiation in vitro.
In vivo studies showed that AOA treatment decreased serum anti-dsDNA antibody and alleviated renal pathologic damage as well as antibody complex accumulation in the pristane-induced LN model.
These results demonstrated that AOA can improve the clinical manifestation of LN, indicating potential application in SLE therapy.
American Psychological Association (APA)
Zhou, Xiaoqing& Chen, Huanpeng& Wei, Fengjiao& Zhao, Qingyu& Su, Qiao& Liang, Jinhao…[et al.]. 2019. 3β-Acetyloxy-oleanolic Acid Attenuates Pristane-Induced Lupus Nephritis by Regulating Th17 Differentiation. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1175856
Modern Language Association (MLA)
Zhou, Xiaoqing…[et al.]. 3β-Acetyloxy-oleanolic Acid Attenuates Pristane-Induced Lupus Nephritis by Regulating Th17 Differentiation. Journal of Immunology Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1175856
American Medical Association (AMA)
Zhou, Xiaoqing& Chen, Huanpeng& Wei, Fengjiao& Zhao, Qingyu& Su, Qiao& Liang, Jinhao…[et al.]. 3β-Acetyloxy-oleanolic Acid Attenuates Pristane-Induced Lupus Nephritis by Regulating Th17 Differentiation. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1175856
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175856