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A Novel Anti-EGFR mAb Ame55 with Lower Toxicity and Better Efficacy than Cetuximab When Combined with Irinotecan
Joint Authors
Pang, Bo
Qiu, Weiyi
Zhang, Chang
Wang, Shuang
Yu, Xiaoyan
Wang, Qiong
Zeng, Dadi
Du, Peng
Ma, Jinling
Zheng, Yiqiong
Yu, Yunzhou
Long, Feng
Pang, Xiaobin
Sun, Zhiwei
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
To improve efficacy and minimize toxicity of EGFR inhibition treatment, we developed Ame55, a novel anti-EGFR IgG1 with lower affinity to EGFR than cetuximab (C225) from a human phage library.
Ame55 had lower bioactivity than cetuximab in vitro but similar antitumor efficacy as cetuximab in vivo.
Moreover, Ame55 was more efficacious than cetuximab in a Lovo cell xenograft tumor model when combined with irinotecan (CPT-11).
Ame55 concentrates in the mouse xenograft tumor and has less toxicity than cetuximab in cynomolgus monkeys in an overdose study.
American Psychological Association (APA)
Qiu, Weiyi& Zhang, Chang& Wang, Shuang& Yu, Xiaoyan& Wang, Qiong& Zeng, Dadi…[et al.]. 2019. A Novel Anti-EGFR mAb Ame55 with Lower Toxicity and Better Efficacy than Cetuximab When Combined with Irinotecan. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1175943
Modern Language Association (MLA)
Qiu, Weiyi…[et al.]. A Novel Anti-EGFR mAb Ame55 with Lower Toxicity and Better Efficacy than Cetuximab When Combined with Irinotecan. Journal of Immunology Research No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1175943
American Medical Association (AMA)
Qiu, Weiyi& Zhang, Chang& Wang, Shuang& Yu, Xiaoyan& Wang, Qiong& Zeng, Dadi…[et al.]. A Novel Anti-EGFR mAb Ame55 with Lower Toxicity and Better Efficacy than Cetuximab When Combined with Irinotecan. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1175943
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1175943