Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor
Joint Authors
Slutsky, Rebecca
Romero, Roberto
Xu, Yi
Galaz, Jose
Miller, Derek
Done, Bogdan
Tarca, Adi L.
Gregor, Sabrina
Hassan, Sonia S.
Leng, Yaozhu
Gomez-Lopez, Nardhy
Source
Journal of Immunology Research
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-23
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Successful pregnancy requires a tightly-regulated equilibrium of immune cell interactions at the maternal-fetal interface (i.e., the decidual tissues), which plays a central role in the inflammatory process of labor.
Most of the innate immune cells in this compartment have been well characterized; however, adaptive immune cells are still under investigation.
Herein, we performed immunophenotyping of the decidua basalis and decidua parietalis to determine whether exhausted and senescent T cells are present at the maternal-fetal interface and whether the presence of pathological (i.e., preterm) or physiological (i.e., term) labor and/or placental inflammation alter such adaptive immune cells.
In addition, decidual exhausted T cells were sorted to test their functional status.
We found that (1) exhausted and senescent T cells were present at the maternal-fetal interface and predominantly expressed an effector memory phenotype, (2) exhausted CD4+ T cells increased in the decidua parietalis as gestational age progressed, (3) exhausted CD4+ and CD8+ T cells decreased in the decidua basalis of women who underwent labor at term compared to those without labor, (4) exhausted CD4+ T cells declined with the presence of placental inflammation in the decidua basalis of women with preterm labor, (5) exhausted CD8+ T cells decreased with the presence of placental inflammation in the decidua basalis of women who underwent labor at term, (6) both senescent CD4+ and CD8+ T cells declined with the presence of placental inflammation in the decidua basalis of women who underwent preterm labor, and (7) decidual exhausted T cells produced IFNγ and TNFα upon in vitro stimulation.
Collectively, these findings indicate that exhausted and senescent T cells are present at the human maternal-fetal interface and undergo alterations in a subset of women either with labor at term or preterm labor and placental inflammation.
Importantly, decidual T cell function can be restored upon stimulation.
American Psychological Association (APA)
Slutsky, Rebecca& Romero, Roberto& Xu, Yi& Galaz, Jose& Miller, Derek& Done, Bogdan…[et al.]. 2019. Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor. Journal of Immunology Research،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1176016
Modern Language Association (MLA)
Slutsky, Rebecca…[et al.]. Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor. Journal of Immunology Research No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1176016
American Medical Association (AMA)
Slutsky, Rebecca& Romero, Roberto& Xu, Yi& Galaz, Jose& Miller, Derek& Done, Bogdan…[et al.]. Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor. Journal of Immunology Research. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1176016
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1176016